Arginine Vasopressin: Direct and Indirect Action on Metabolism

Overview

Journal Peptides

Specialty Biochemistry

Date 2021 Apr 27

PMID 33905792

Citations 20

Authors

Mitsuhiro Yoshimura

Becky Conway-Campbell

Yoichi Ueta

Affiliations

Soon will be listed here.

Abstract

From its identification and isolation in 1954, arginine vasopressin (AVP) has attracted attention, not only for its peripheral functions such as vasoconstriction and reabsorption of water from kidney, but also for its central effects. As there is now considerable evidence that AVP plays a crucial role in feeding behavior and energy balance, it has become a promising therapeutic target for treating obesity or other obesity-related metabolic disorders. However, the underlying mechanisms for AVP regulation of these central processes still remain largely unknown. In this review, we will provide a brief overview of the current knowledge concerning how AVP controls energy balance and feeding behavior, focusing on physiological aspects including the relationship between AVP, circadian rhythmicity, and glucocorticoids.

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