Cumulative Risks of Colorectal Cancer in Han Chinese Patients with Lynch Syndrome in Taiwan

Overview

Journal Sci Rep

Specialty Science

Date 2021 Apr 27

PMID 33903664

Citations 2

Authors

Abram Bunya Kamiza

Wen-Chang Wang

Jeng-Fu You

Reiping Tang

Huei-Tzu Chien

Chih-Hsiung Lai

Li-Ling Chiu

Tsai-Ping Lo

Kuan-Yi Hung

Chao A Hsiung

Chih-Ching Yeh

Affiliations

Soon will be listed here.

Abstract

Patients with Lynch syndrome have a high risk of colorectal cancer (CRC). In this study, we estimated the age- and sex-specific cumulative risks of CRC in Han Chinese patients with Lynch syndrome caused by the pathogenic germline mutations in MLH1 or MSH2 in Taiwan. Based on 321 mutation carriers and 419 non-mutation carriers from 75 pedigrees collected in an Amsterdam criteria family registry in Taiwan, the age- and sex-specific cumulative risks of CRC in male carriers of mutation in MLH1 and MSH2 at the age of 70 years were 60.3% (95% confidence interval (CI) = 31.1%-89.9%) and 76.7% (95% CI = 37.2%-99.0%), respectively. For females, the cumulative risks of CRC at the age of 70 were estimated to be 30.6% (95% CI = 14.3%-57.7%) and 49.3% (95% CI = 21.9%-84.5%) in the carriers of MLH1 and MSH2 germline mutations, respectively. In conclusion, the cumulative risks of CRC at the age of 70 in the Han Chinese patients is higher in mutation carriers than non-mutation carriers and male mutation carriers have a higher cumulative risk of developing CRC than the female mutation carriers.

Citing Articles

[Gender-specific differences in the development of colorectal cancer in Lynch syndrome patients-A systematic review].

Dohmen J, Sommer N, van Beekum K, Nattermann J, Engel C, Kalff J Chirurgie (Heidelb). 2024; 95(9):696-708.

PMID: 39145869 DOI: 10.1007/s00104-024-02159-x.

Genitourinary manifestations of Lynch syndrome in the urological practice.

Lonati C, Simeone C, Suardi N, Spiess P, Necchi A, Moschini M Asian J Urol. 2022; 9(4):443-450.

PMID: 36381590 PMC: 9643301. DOI: 10.1016/j.ajur.2022.05.009.

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