[A Review on Cell-based Models of Human Liver Disease in Vitro]

Overview

Journal Sheng Wu Yi Xue Gong Cheng Xue Za Zhi

Specialty Biomedical Engineering

Date 2021 Apr 26

PMID 33899443

Authors

Ting Liu

Yuqing Ge

Min Yuan

Qiao Xiong

Jianlong Zhao

Affiliations

Soon will be listed here.

Abstract

Unhealthy diet, habits and drug abuse cause a variety of liver diseases, including steatohepatitis, liver fibrosis, liver cirrhosis and liver cancer, which seriously affect human health. The fabrication of highly simulated cell models in vitro is important in the treatment of liver diseases and drug development. This article summarized the common strategies for the construction of liver pathology models . It introduced four typical cell models related to liver disease and provided a reference for the study of liver disease models.

References

Vilas-Boas V, Cooreman A, Gijbels E, Van Campenhout R, Gustafson E, Ballet S . Primary hepatocytes and their cultures for the testing of drug-induced liver injury. Adv Pharmacol. 2019; 85:1-30. DOI: 10.1016/bs.apha.2018.08.001. View

Li M, Wang Z, Zhang L, Zheng H, Liu D, Zhou M . Burden of Cirrhosis and Other Chronic Liver Diseases Caused by Specific Etiologies in China, 1990-2016: Findings from the Global Burden of Disease Study 2016. Biomed Environ Sci. 2020; 33(1):1-10. DOI: 10.3967/bes2020.001. View

Nguyen D, Funk J, Robbins J, Crogan-Grundy C, Presnell S, Singer T . Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro. PLoS One. 2016; 11(7):e0158674. PMC: 4936711. DOI: 10.1371/journal.pone.0158674. View

Rizki-Safitri A, Shinohara M, Tanaka M, Sakai Y . Tubular bile duct structure mimicking bile duct morphogenesis for prospective in vitro liver metabolite recovery. J Biol Eng. 2020; 14:11. PMC: 7081557. DOI: 10.1186/s13036-020-0230-z. View

Baze A, Parmentier C, Hendriks D, Hurrell T, Heyd B, Bachellier P . Three-Dimensional Spheroid Primary Human Hepatocytes in Monoculture and Coculture with Nonparenchymal Cells. Tissue Eng Part C Methods. 2018; 24(9):534-545. DOI: 10.1089/ten.TEC.2018.0134. View

Mahli A, Koch A, Fresse K, Schiergens T, Thasler W, Schonberger C . Iso-alpha acids from hops (Humulus lupulus) inhibit hepatic steatosis, inflammation, and fibrosis. Lab Invest. 2018; 98(12):1614-1626. DOI: 10.1038/s41374-018-0112-x. View

Jang K, Otieno M, Ronxhi J, Lim H, Ewart L, Kodella K . Reproducing human and cross-species drug toxicities using a Liver-Chip. Sci Transl Med. 2019; 11(517). DOI: 10.1126/scitranslmed.aax5516. View

Suurmond C, Lasli S, van den Dolder F, Ung A, Kim H, Bandaru P . In Vitro Human Liver Model of Nonalcoholic Steatohepatitis by Coculturing Hepatocytes, Endothelial Cells, and Kupffer Cells. Adv Healthc Mater. 2019; 8(24):e1901379. DOI: 10.1002/adhm.201901379. View

Mukherjee S, Zhelnin L, Sanfiz A, Pan J, Li Z, Yarde M . Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype. Am J Transl Res. 2019; 11(3):1531-1540. PMC: 6456529. View

10.

Underhill G, Khetani S . Bioengineered Liver Models for Drug Testing and Cell Differentiation Studies. Cell Mol Gastroenterol Hepatol. 2018; 5(3):426-439.e1. PMC: 5904032. DOI: 10.1016/j.jcmgh.2017.11.012. View

11.

Ware B, Durham M, Monckton C, Khetani S . A Cell Culture Platform to Maintain Long-term Phenotype of Primary Human Hepatocytes and Endothelial Cells. Cell Mol Gastroenterol Hepatol. 2018; 5(3):187-207. PMC: 5782488. DOI: 10.1016/j.jcmgh.2017.11.007. View

12.

Andrade R, Chalasani N, Bjornsson E, Suzuki A, Kullak-Ublick G, Watkins P . Drug-induced liver injury. Nat Rev Dis Primers. 2019; 5(1):58. DOI: 10.1038/s41572-019-0105-0. View

13.

March S, Ramanan V, Trehan K, Ng S, Galstian A, Gural N . Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens. Nat Protoc. 2015; 10(12):2027-53. PMC: 5867906. DOI: 10.1038/nprot.2015.128. View

14.

Bedossa P . Pathology of non-alcoholic fatty liver disease. Liver Int. 2017; 37 Suppl 1:85-89. DOI: 10.1111/liv.13301. View

15.

Ewart L, Dehne E, Fabre K, Gibbs S, Hickman J, Hornberg E . Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery. Annu Rev Pharmacol Toxicol. 2017; 58:65-82. DOI: 10.1146/annurev-pharmtox-010617-052722. View

16.

Bao C, Hung H, Chen Y, Fan C, Huang C, Huang W . Requirement of cyclin-dependent kinase function for hepatitis B virus cccDNA synthesis as measured by digital PCR. Ann Hepatol. 2020; 19(3):280-286. DOI: 10.1016/j.aohep.2019.12.005. View

17.

Talman A, Blagborough A, Sinden R . A Plasmodium falciparum strain expressing GFP throughout the parasite's life-cycle. PLoS One. 2010; 5(2):e9156. PMC: 2819258. DOI: 10.1371/journal.pone.0009156. View

18.

Gural N, Mancio-Silva L, Miller A, Galstian A, Butty V, Levine S . In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites. Cell Host Microbe. 2018; 23(3):395-406.e4. PMC: 8048090. DOI: 10.1016/j.chom.2018.01.002. View

19.

Paran N, Geiger B, Shaul Y . HBV infection of cell culture: evidence for multivalent and cooperative attachment. EMBO J. 2001; 20(16):4443-53. PMC: 125578. DOI: 10.1093/emboj/20.16.4443. View

20.

Bessone F, Razori M, Roma M . Molecular pathways of nonalcoholic fatty liver disease development and progression. Cell Mol Life Sci. 2018; 76(1):99-128. PMC: 11105781. DOI: 10.1007/s00018-018-2947-0. View