The Nuclear Functions of Long Noncoding RNAs Come into Focus
Overview
Affiliations
Long noncoding RNAs (lncRNAs), defined as untranslated and tightly-regulated transcripts with a length exceeding 200 nt, are common outputs of the eukaryotic genome. It is becoming increasingly apparent that many lncRNAs likely serve as important regulators in a variety of biological processes. In particular, some of them accumulate in the nucleus and function in diverse nuclear events, including chromatin remodeling, transcriptional regulation, RNA processing, DNA damage repair, etc. Here, we unite recent progresses on the functions of nuclear lncRNAs and provide insights into the future research directions of this field.
Non-coding RNAs and neuroinflammation: implications for neurological disorders.
Chen Y, Mateski J, Gerace L, Wheeler J, Burl J, Prakash B Exp Biol Med (Maywood). 2024; 249:10120.
PMID: 38463392 PMC: 10911137. DOI: 10.3389/ebm.2024.10120.
The Role of Noncoding RNA in the Transmission and Pathogenicity of Flaviviruses.
Zhang X, Li Y, Cao Y, Wu Y, Cheng G Viruses. 2024; 16(2).
PMID: 38400018 PMC: 10892091. DOI: 10.3390/v16020242.
Huang X, Huang J, Huang Q, Zhou S Transl Cancer Res. 2024; 12(12):3653-3671.
PMID: 38193005 PMC: 10774046. DOI: 10.21037/tcr-23-147.
The functions of long non-coding RNA (lncRNA)-MALAT-1 in the pathogenesis of renal cell carcinoma.
Anbiyaee O, Moalemnia A, Ghaedrahmati F, Khombi Shooshtari M, Khoshnam S, Kempisty B BMC Nephrol. 2023; 24(1):380.
PMID: 38124072 PMC: 10731893. DOI: 10.1186/s12882-023-03438-1.
LncRNA MALAT1 and Ischemic Stroke: Pathogenesis and Opportunities.
Khoshnam S, Moalemnia A, Anbiyaee O, Farzaneh M, Ghaderi S Mol Neurobiol. 2023; 61(7):4369-4380.
PMID: 38087169 DOI: 10.1007/s12035-023-03853-3.