Dermatologic Toxicities Associated with Radiation Therapy in Women with Breast Cancer

Overview

Journal Int J Womens Dermatol

Publisher Wolters Kluwer

Date 2021 Apr 26

PMID 33898697

Citations 20

Authors

Julie Y Ramseier

Michelle N Ferreira

Jonathan S Leventhal

Affiliations

Soon will be listed here.

Abstract

Breast-conserving surgery with adjuvant radiation therapy has become the standard of care for women with early stage breast cancer, and as a result, a large number of patients are affected by the cutaneous sequelae of radiation therapy. These dermatologic toxicities may present during treatment or years later and can significantly impact patients' quality of life. In this review, we discuss the clinical presentation, prevention, and management of radiation-induced cutaneous toxicities in women with breast cancer, including radiation dermatitis, radiation recall, radiation-induced morphea, radiation-induced fibrosis, and cutaneous malignancies in irradiated skin.

Citing Articles

Ultrasound Findings After Breast Cancer Radiation Therapy: Cutaneous, Pleural, Pulmonary, and Cardiac Changes.

Catalano O, Fusco R, Carriero S, Tamburrini S, Granata V Korean J Radiol. 2024; 25(11):982-991.

PMID: 39473089 PMC: 11524688. DOI: 10.3348/kjr.2024.0672.

Utilizing radiomics and dosiomics with AI for precision prediction of radiation dermatitis in breast cancer patients.

Lee T, Chang C, Chi C, Liu Y, Shao J, Hsieh Y BMC Cancer. 2024; 24(1):965.

PMID: 39107701 PMC: 11304569. DOI: 10.1186/s12885-024-12753-1.

Breast Radiation Therapy Survivorship and Cancer Support Groups: an Opportunity for Community Engagement and Education Through the Addressing Breast Cancer Dermatologic Side Effects (ABCDEs) Program.

Veluri S, Park J, Anderson C, Asper J, Walsh M, Bonnen M J Cancer Educ. 2024; 40(1):93-101.

PMID: 39069600 DOI: 10.1007/s13187-024-02477-y.

Metabolomics in Radiotherapy-Induced Early Adverse Skin Reactions of Breast Cancer Patients.

McMahon A, Lee E, Takita C, Reis I, Wright J, Hu J Breast Cancer (Dove Med Press). 2024; 16:369-377.

PMID: 39050765 PMC: 11268658. DOI: 10.2147/BCTT.S466521.

Cosmetic considerations after breast cancer treatment.

Rose L, Mallela T, Waters M, Novice M, Minta A, Akintilo L Arch Dermatol Res. 2024; 316(6):223.

PMID: 38787423 DOI: 10.1007/s00403-024-02898-1.

References

Shaw S, Nien H, Wu C, Lui L, Su J, Lang C . 3M Cavilon No-Sting Barrier Film or topical corticosteroid (mometasone furoate) for protection against radiation dermatitis: A clinical trial. J Formos Med Assoc. 2013; 114(5):407-14. DOI: 10.1016/j.jfma.2013.04.003. View

Laffin N, Smyth W, Heyer E, Fasugba O, Abernethy G, Gardner A . Effectiveness and Acceptability of a Moisturizing Cream and a Barrier Cream During Radiation Therapy for Breast Cancer in the Tropics: A Randomized Controlled Trial. Cancer Nurs. 2014; 38(3):205-14. DOI: 10.1097/NCC.0000000000000161. View

Simone N, Soule B, Gerber L, Augustine E, Smith S, Altemus R . Oral pirfenidone in patients with chronic fibrosis resulting from radiotherapy: a pilot study. Radiat Oncol. 2007; 2:19. PMC: 1891306. DOI: 10.1186/1748-717X-2-19. View

McGale P, Taylor C, Correa C, Cutter D, Duane F, Ewertz M . Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet. 2014; 383(9935):2127-35. PMC: 5015598. DOI: 10.1016/S0140-6736(14)60488-8. View

Cuperus E, Leguit R, Albregts M, Toonstra J . Post radiation skin tumors: basal cell carcinomas, squamous cell carcinomas and angiosarcomas. A review of this late effect of radiotherapy. Eur J Dermatol. 2013; 23(6):749-57. DOI: 10.1684/ejd.2013.2106. View

Sholl L, Barletta J, Hornick J . Radiation-associated neoplasia: clinical, pathological and genomic correlates. Histopathology. 2016; 70(1):70-80. DOI: 10.1111/his.13069. View

Singh M, Alavi A, Wong R, Akita S . Radiodermatitis: A Review of Our Current Understanding. Am J Clin Dermatol. 2016; 17(3):277-92. DOI: 10.1007/s40257-016-0186-4. View

Schaffer J, Carroll C, Dvoretsky I, Huether M, Girardi M . Postirradiation morphea of the breast presentation of two cases and review of the literature. Dermatology. 2000; 200(1):67-71. DOI: 10.1159/000018322. View

Wengstrom Y, Haggmark C, Forsberg C . Coping with radiation therapy: strategies used by women with breast cancer. Cancer Nurs. 2001; 24(4):264-71. DOI: 10.1097/00002820-200108000-00003. View

10.

Buehler D, Rice S, Moody J, Rush P, Hafez G, Attia S . Angiosarcoma outcomes and prognostic factors: a 25-year single institution experience. Am J Clin Oncol. 2013; 37(5):473-9. PMC: 3664266. DOI: 10.1097/COC.0b013e31827e4e7b. View

11.

Connolly S, Baker D, Coldiron B, Fazio M, Storrs P, Vidimos A . AAD/ACMS/ASDSA/ASMS 2012 appropriate use criteria for Mohs micrographic surgery: a report of the American Academy of Dermatology, American College of Mohs Surgery, American Society for Dermatologic Surgery Association, and the American Society for.... J Am Acad Dermatol. 2012; 67(4):531-50. DOI: 10.1016/j.jaad.2012.06.009. View

12.

Uzun G, Candas F, Mutluoglu M, Ay H . Successful treatment of soft tissue radionecrosis injury with hyperbaric oxygen therapy. BMJ Case Rep. 2013; 2013. PMC: 3736394. DOI: 10.1136/bcr-2013-009555. View

13.

Melnyk S, More K, Miles E . Idiopathic radiation recall dermatitis developing nine months after cessation of Cisplatin therapy in treatment of squamous cell carcinoma of the tonsil. Case Rep Oncol Med. 2012; 2012:271801. PMC: 3382264. DOI: 10.1155/2012/271801. View

14.

Ronen S, Ivan D, Torres-Cabala C, Curry J, Tetzlaff M, Aung P . Post-radiation vascular lesions of the breast. J Cutan Pathol. 2018; 46(1):52-58. DOI: 10.1111/cup.13363. View

15.

Rees F, Doherty M, Grainge M, Lanyon P, Zhang W . The worldwide incidence and prevalence of systemic lupus erythematosus: a systematic review of epidemiological studies. Rheumatology (Oxford). 2017; 56(11):1945-1961. DOI: 10.1093/rheumatology/kex260. View

16.

Billings S, McKenney J, Folpe A, Hardacre M, Weiss S . Cutaneous angiosarcoma following breast-conserving surgery and radiation: an analysis of 27 cases. Am J Surg Pathol. 2004; 28(6):781-8. DOI: 10.1097/01.pas.0000126055.33916.0b. View

17.

Bourgeois A, Grisoli S, Soine E, Rosen L . Tamoxifen-induced radiation recall dermatitis. Dermatol Online J. 2017; 23(2). View

18.

Dion M, Hussey D, Doornbos J, Vigliotti A, Wen B, Anderson B . Preliminary results of a pilot study of pentoxifylline in the treatment of late radiation soft tissue necrosis. Int J Radiat Oncol Biol Phys. 1990; 19(2):401-7. DOI: 10.1016/0360-3016(90)90549-y. View

19.

Shaitelman S, Schlembach P, Arzu I, Ballo M, Bloom E, Buchholz D . Acute and Short-term Toxic Effects of Conventionally Fractionated vs Hypofractionated Whole-Breast Irradiation: A Randomized Clinical Trial. JAMA Oncol. 2015; 1(7):931-41. PMC: 4635441. DOI: 10.1001/jamaoncol.2015.2666. View

20.

Fruchter R, Kurtzman D, Mazori D, Wright N, Patel M, Vleugels R . Characteristics and treatment of postirradiation morphea: A retrospective multicenter analysis. J Am Acad Dermatol. 2016; 76(1):19-21. DOI: 10.1016/j.jaad.2016.08.059. View