Correlation Between Neutrophil-to-lymphocyte Ratio with Gleason Score in Patients with Prostate Cancer at Adam Malik Hospital Medan 2013 - 2015

Context: A grading system was created by Donald F. Gleason for prostate cancer as prognostic indicators. The neutrophil-to-lymphocyte ratio (NLR) was found that it could be a prognostic factor in solid tumors.

Aims: This study aims to assess whether there is a correlation between NLR with the results of the Gleason score of patients with prostate adenocarcinoma biopsy at Haji Adam Malik Hospital Medan.

Settings And Design: A total of 121 patients underwent a prostate biopsy from early January 2013 to December 2015 at Adam Malik Hospital.

Subjects And Methods: Of the 121 patients, thirty were not included in the study because of incomplete baseline data and a history of hematological abnormalities. Data from 91 patients were then taken, including age, hematologic data prebiopsy, prostate-specific antigen (PSA) on initial examination, prostate weight estimation, and Gleason scores from biopsy results.

Statistical Analysis Used: The data are processed with SPSS version 22.

Results: A significant moderate strength correlation was found between NLR and Gleason Score ( = 0.572; = 0.001). However, no statistically significant correlation found between NLR and prostate weight estimation ( = 0.077; = 0.469) and NLR with PSA ( = 0.072; = 0.496).

Conclusions: A significant correlation between the neutrophil-to-lymphocyte ratio and the Gleason score was noted. Further studies are needed to confirm these findings.