Uterine Natural Killer Cells and Recurrent Spontaneous Abortion

Overview

Journal Am J Reprod Immunol

Specialties Allergy & Immunology
Reproductive Medicine

Date 2021 Apr 25

PMID 33896061

Citations 15

Authors

Yao-Yao Fu

Chun-E Ren

Peng-Yun Qiao

Yu-Han Meng

Affiliations

Soon will be listed here.

Abstract

Recurrent spontaneous abortion (RSA), termed as two or more consecutive pregnancy loss is a great problem for some women of childbearing age. A large number of evidence confirm that there may be an immune background of RSA. As a member of the innate immune system, uterine natural killer (uNK) cells account for about 70% of total lymphocytes during pregnancy and play a critical role in the establishment and maintenance of pregnancy. This review mainly introduces the phenotype, origin, receptor, and function of uNK cells to illuminate its relationship with RSA.

Citing Articles

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Beyond Immune Balance: The Pivotal Role of Decidual Regulatory T Cells in Unexplained Recurrent Spontaneous Abortion.

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