Pulmonary Hypertension As a Complication of Pediatric Cancer

Overview

Journal Glob Pediatr Health

Specialty Pediatrics

Date 2021 Apr 23

PMID 33889681

Citations 3

Authors

Edward C Kirkpatrick

Affiliations

Soon will be listed here.

Abstract

Pediatric cancer is a life threatening disease known to create multi-organ complications that further compromise medical management affecting patient morbidity and mortality. Pulmonary hypertension (PH) is becoming more recognized as a complication of cancer and its therapies but has not been well characterized in pediatrics. Cancer pathophysiology can be uniquely set up to promote pulmonary vascular injury and remodeling that is similar to PH patients without cancer. This highlights the need to evaluate for PH clinically and with routine testing such as echocardiography during the course of a patient's care even into adulthood. This review article will discuss the direct, indirect and therapy related aspects of cancer which can promote PH in these patients. This understanding is essential to target effective treatment options in a potentially fatal complication. Diagnostic and treatment algorithms are presented in relation to the most recent pediatric PH management guidelines.

Citing Articles

Cancer Therapy-Associated Pulmonary Hypertension and Right Ventricular Dysfunction: Etiologies and Prognostic Implications.

Leiva O, Beaty W, Soo S, Agarwal M, Yang E Rev Cardiovasc Med. 2024; 25(3):87.

PMID: 39076943 PMC: 11263834. DOI: 10.31083/j.rcm2503087.

Cancer Therapy-Related Pulmonary Hypertension: A Review of Mechanisms and Implications for Clinical Practice.

Gurdogan M, Demir M, Yalta K, Gulertop Y Anatol J Cardiol. 2023; 27(6):299-307.

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Maternal Cardiovascular Outcomes of Pregnancy in Childhood, Adolescent, and Young Adult Cancer Survivors.

Bansal N, Fernandez Hazim C, Badillo S, Shyam S, Wolfe D, Bortnick A J Cardiovasc Dev Dis. 2022; 9(11).

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