Three New Sesquiterpene Lactones from the Whole Plants of

Three new sesquiterpene lactones, named scabertopinolides H - J (-), along with four known ones, desacylisodeoxyelephantopin 2-methylbutyrate (), iso-17,19-dihydrodeoxyelephantopin (), scabertopinolide D () and 6,7,8)-8-tigloyloxy-1(10),4(5),11(13)-germacratrien-2,15,6,12-diolide () were isolated from the whole plants of . Their structures were elucidated by extensive analysis of spectroscopic data (including IR, UV, HRESIMS, 1 D and 2 D NMR) and single-crystal X-ray. These isolated compounds showed effective anti-inflammatory effects on LPS-stimulated RAW 264.7 cells with IC values of 6.27 ± 0.18 to 18.31 ± 1.38 μM.