[Cushing's Syndrome with Subsequent Tertiary Adrenocortical Insufficiency After Simultaneous Multiple Intra-articular Local Glucocorticoid Treatment : Keep an Eye on Hormone Deficiency Conditions Requiring Treatment After Multiple Administrations Of...]

After simultaneous multiple local treatment with glucocorticoids at 46 sites a 4‑year-old female patient with newly diagnosed polyarticular juvenile idiopathic arthritis (JIA) initially developed Cushing's syndrome followed by a gradual worsening of her condition and finally an acute high fever urinary tract infection. Iatrogenic adrenocortical insufficiency after multiple intra-articular glucocorticoid administration was diagnosed. The possibility of severe systemic glucocorticoid side effects after extensive local treatment should be included in the regular management of JIA patients.