Current Applications and Prospects of Nanoparticles for Antifungal Drug Delivery

Overview

Journal EXCLI J

Specialty Biology

Date 2021 Apr 22

PMID 33883983

Citations 14

Authors

Sanam Nami

Ali Aghebati-Maleki

Leili Aghebati-Maleki

Affiliations

Soon will be listed here.

Abstract

Currently, the significance of fungi as human pathogens is not medically concealed in the world. Consequently, suitable recognition and treatment of such infections are of great importance and necessitate the need for comprehensive information in this regard. The introduction of new antifungals and their use today, especially in the last two decades, have revolutionized the treatment of fungal infections. On the other hand, increasing drug resistance in the world has overshadowed such developments. The use of NPs results in the treatment of fungal infections and owing to their specific properties, these particles, unlike the pure antibiotics, can exert a greater inhibitory power although with less concentration compared with conventional drugs. Important reasons that have led to the use of antifungal drugs in delivery systems include reduced drug efficacy, limited penetration through tissue, poor aqueous solubility, decreased bioavailability, and poor drug pharmacokinetics. It is therefore hoped that unfavorable properties of antifungal drugs be mitigated via their incorporation into different types of NPs. This review summarizes the different types of NPs as delivery systems of antifungal as well as their advantages over pure drugs.

Citing Articles

Calcofluor White-Phosphatidylethanolamine Conjugate-Enhanced Ethosomal Delivery of Voriconazole for Targeting .

Shen T, Li M, Tian B, Liu W, Chu L, Yu P Int J Nanomedicine. 2024; 19:13047-13069.

PMID: 39654804 PMC: 11626965. DOI: 10.2147/IJN.S488456.

Manipulation of host phagocytosis by fungal pathogens and therapeutic opportunities.

Jia L, Gonzalez K, Orasch T, Schmidt F, Brakhage A Nat Microbiol. 2024; 9(9):2216-2231.

PMID: 39187614 DOI: 10.1038/s41564-024-01780-0.

Naringenin-Zinc Oxide Nanocomposites Amalgamated Polymeric Gel Augmented Drug Delivery and Attenuated Experimental Cutaneous Candidiasis in Balb/c Mice: In Vitro and In Vivo Studies.

Katta C, Bahuguna D, Veerabomma H, Gollapalli S, Sujat Shaikh A, Bhale N AAPS PharmSciTech. 2024; 25(5):130.

PMID: 38844611 DOI: 10.1208/s12249-024-02841-7.

Advances in the Optimization of Fe Nanoparticles: Unlocking Antifungal Properties for Biomedical Applications.

Sandhu Z, Raza M, Alqurashi A, Sajid S, Ashraf S, Imtiaz K Pharmaceutics. 2024; 16(5).

PMID: 38794307 PMC: 11124843. DOI: 10.3390/pharmaceutics16050645.

Nanoparticles assisted intra and transdermic delivery of antifungal ointment: an updated review.

Tarannum N, Pooja K, Jakhar S, Mavi A Discov Nano. 2024; 19(1):11.

PMID: 38195832 PMC: 10776542. DOI: 10.1186/s11671-023-03932-3.

References

Antoniraj M, Ayyavu M, Henry L, Nageshwar Rao G, Natesan S, Sundar D . Cytocompatible chitosan-graft-mPEG-based 5-fluorouracil-loaded polymeric nanoparticles for tumor-targeted drug delivery. Drug Dev Ind Pharm. 2017; 44(3):365-376. DOI: 10.1080/03639045.2017.1371741. View

Yang Z, Tan Y, Chen M, Dian L, Shan Z, Peng X . Development of amphotericin B-loaded cubosomes through the SolEmuls technology for enhancing the oral bioavailability. AAPS PharmSciTech. 2012; 13(4):1483-91. PMC: 3513470. DOI: 10.1208/s12249-012-9876-2. View

Balabathula P, Whaley S, Janagam D, Mittal N, Mandal B, Thoma L . Lyophilized Iron Oxide Nanoparticles Encapsulated in Amphotericin B: A Novel Targeted Nano Drug Delivery System for the Treatment of Systemic Fungal Infections. Pharmaceutics. 2020; 12(3). PMC: 7150906. DOI: 10.3390/pharmaceutics12030247. View

Trombino S, Mellace S, Cassano R . Solid lipid nanoparticles for antifungal drugs delivery for topical applications. Ther Deliv. 2016; 7(9):639-47. DOI: 10.4155/tde-2016-0040. View

Fu T, Yi J, Lv S, Zhang B . Ocular amphotericin B delivery by chitosan-modified nanostructured lipid carriers for fungal keratitis-targeted therapy. J Liposome Res. 2016; 27(3):228-233. DOI: 10.1080/08982104.2016.1224899. View

Yang Z, Chen M, Yang M, Chen J, Fang W, Xu P . Evaluating the potential of cubosomal nanoparticles for oral delivery of amphotericin B in treating fungal infection. Int J Nanomedicine. 2014; 9:327-36. PMC: 3888350. DOI: 10.2147/IJN.S54967. View

Mohammed N, Rejinold N, Mangalathillam S, Biswas R, Nair S, Jayakumar R . Fluconazole loaded chitin nanogels as a topical ocular drug delivery agent for corneal fungal infections. J Biomed Nanotechnol. 2013; 9(9):1521-31. DOI: 10.1166/jbn.2013.1647. View

Zhang J, Luan F, Li Q, Gu G, Dong F, Guo Z . Synthesis of Novel Chitin Derivatives Bearing Amino Groups and Evaluation of Their Antifungal Activity. Mar Drugs. 2018; 16(10). PMC: 6212816. DOI: 10.3390/md16100380. View

Lucena P, Nascimento T, Gaeti M, de Avila R, Mendes L, Vieira M . Vaginal Fungal Load Reduction After Treatment with Itraconazole-Loaded Polycaprolactone-Nanoparticles. J Biomed Nanotechnol. 2018; 14(7):1347-1358. DOI: 10.1166/jbn.2018.2574. View

10.

Chandasana H, Durga Prasad Y, Chhonker Y, Chaitanya T, Mishra N, Mitra K . Corneal targeted nanoparticles for sustained natamycin delivery and their PK/PD indices: an approach to reduce dose and dosing frequency. Int J Pharm. 2014; 477(1-2):317-25. DOI: 10.1016/j.ijpharm.2014.10.035. View

11.

Mu L, Feng S . A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS. J Control Release. 2002; 86(1):33-48. DOI: 10.1016/s0168-3659(02)00320-6. View

12.

Lopez M, Miranda E, Ramos C, Garcia H, Neira-Carrillo A . Activation of Early Defense Signals in Seedlings of Treated with Chitin Nanoparticles. Plants (Basel). 2020; 9(5). PMC: 7284726. DOI: 10.3390/plants9050607. View

13.

Souto E, Wissing S, Barbosa C, Muller R . Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery. Int J Pharm. 2004; 278(1):71-7. DOI: 10.1016/j.ijpharm.2004.02.032. View

14.

Chhonker Y, Durga Prasad Y, Chandasana H, Vishvkarma A, Mitra K, Shukla P . Amphotericin-B entrapped lecithin/chitosan nanoparticles for prolonged ocular application. Int J Biol Macromol. 2014; 72:1451-8. DOI: 10.1016/j.ijbiomac.2014.10.014. View

15.

Hussain M, Ahmed D, Anwar A, Perveen S, Ahmed S, Anis I . Combination Therapy of Clinically Approved Antifungal Drugs Is Enhanced by Conjugation with Silver Nanoparticles. Int Microbiol. 2019; 22(2):239-246. DOI: 10.1007/s10123-018-00043-3. View

16.

Furedi P, Papay Z, Kovacs K, Dalmadi Kiss B, Ludanyi K, Antal I . Development and characterization of the voriconazole loaded lipid-based nanoparticles. J Pharm Biomed Anal. 2016; 132:184-189. DOI: 10.1016/j.jpba.2016.09.047. View

17.

Ahmed T, Aljaeid B . A potential in situ gel formulation loaded with novel fabricated poly(lactide-co-glycolide) nanoparticles for enhancing and sustaining the ophthalmic delivery of ketoconazole. Int J Nanomedicine. 2017; 12:1863-1875. PMC: 5352245. DOI: 10.2147/IJN.S131850. View

18.

Moghimipour E, Aghel N, Zarei Mahmoudabadi A, Ramezani Z, Handali S . Preparation and Characterization of Liposomes Containing Essential Oil of Eucalyptus camaldulensis Leaf. Jundishapur J Nat Pharm Prod. 2014; 7(3):117-22. PMC: 3941848. View

19.

Mohanty B, Majumdar D, Mishra S, Panda A, Patnaik S . Development and characterization of itraconazole-loaded solid lipid nanoparticles for ocular delivery. Pharm Dev Technol. 2014; 20(4):458-64. DOI: 10.3109/10837450.2014.882935. View

20.

Sandhya M, V A, Maneesha K S, Raja B, R J, S S . Amphotericin B loaded sulfonated chitosan nanoparticles for targeting macrophages to treat intracellular Candida glabrata infections. Int J Biol Macromol. 2018; 110:133-139. DOI: 10.1016/j.ijbiomac.2018.01.028. View