Oxazolone-induced Gastrointestinal Disorders Enhance the Oral Transmission of AA Amyloidosis in Mice

Overview

Journal J Vet Med Sci

Specialty Veterinary Medicine

Date 2021 Apr 22

PMID 33883362

Citations 1

Authors

Hiroto Kobayashi

Susumu Iwaide

Naoki Ujike

Tomoaki Murakami

Affiliations

Soon will be listed here.

Abstract

Amyloid A (AA) amyloidosis is a lethal disease characterized by systemic AA amyloid deposition, and is reported in many animal species. Despite experiments have shown that AA amyloidosis can be transmitted orally, horizontal transmission and cross-species transmission are concerns, the transmission mechanism has been unknown. In this study, we examined the oral transmission efficiency of AA amyloidosis using oxazolone-induced gastrointestinal disorder mice. As a result, the upper or lower gastrointestinal disorder groups developed more severe amyloid deposition in systemic tissues than the group without gastrointestinal disorders. The results of this study suggest that gastrointestinal damage promotes the oral transmission of AA amyloidosis.

Citing Articles

Local administration of amyloid enhancing factor initiates in situ amyloid A deposition followed by systemic lesions in mice.

Iwaide S, Oba R, Kobayashi N, Murakami T Exp Anim. 2022; 72(2):218-223.

PMID: 36418077 PMC: 10202707. DOI: 10.1538/expanim.22-0125.

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