Leveraging Unstructured Data to Identify Hereditary Angioedema Patients in Electronic Medical Records

Overview

Journal Allergy Asthma Clin Immunol

Specialty Allergy & Immunology

Date 2021 Apr 21

PMID 33879228

Citations 2

Authors

Emily S Brouwer

Emily W Bratton

Aimee M Near

Lynn Sanders

Christina D Mack

Affiliations

Soon will be listed here.

Abstract

Background: The epidemiologic impact of hereditary angioedema (HAE) is difficult to quantify, due to misclassification in retrospective studies resulting from non-specific diagnostic coding. The aim of this study was to identify cohorts of patients with HAE-1/2 by evaluating structured and unstructured data in a US ambulatory electronic medical record (EMR) database.

Methods: A retrospective feasibility study was performed using the GE Centricity EMR Database (2006-2017). Patients with ≥ 1 diagnosis code for HAE-1/2 (International Classification of Diseases, Ninth Revision, Clinical Modification 277.6 or International Classification of Diseases, Tenth Revision, Clinical Modification D84.1) and/or ≥ 1 physician note regarding HAE-1/2 and ≥ 6 months' data before and after the earliest code or note (index date) were included. Two mutually exclusive cohorts were created: probable HAE (≥ 2 codes or ≥ 2 notes on separate days) and suspected HAE (only 1 code or note). The impact of manually reviewing physician notes on cohort formation was assessed, and demographic and clinical characteristics of the 2 final cohorts were described.

Results: Initially, 1691 patients were identified: 190 and 1501 in the probable and suspected HAE cohorts, respectively. After physician note review, the confirmed HAE cohort comprised 254 patients and the suspected HAE cohort decreased to 1299 patients; 138 patients were determined not to have HAE and were excluded. The overall false-positive rate for the initial algorithms was 8.2%. Across final cohorts, the median age was 50 years and > 60% of patients were female. HAE-specific prescriptions were identified for 31% and 2% of the confirmed and suspected HAE cohorts, respectively.

Conclusions: Unstructured EMR data can provide valuable information for identifying patients with HAE-1/2. Further research is needed to develop algorithms for more representative HAE cohorts in retrospective studies.

Citing Articles

Real-world experience of hereditary angioedema (HAE) in Mexico: A mixed-methods approach to describe epidemiology, diagnosis, and treatment patterns.

Nieto S, Madrigal I, Contreras F, Vargas M World Allergy Organ J. 2023; 16(9):100812.

PMID: 37727628 PMC: 10506135. DOI: 10.1016/j.waojou.2023.100812.

Effectiveness and safety of lanadelumab in ethnic and racial minority subgroups of patients with hereditary angioedema: results from phase 3 studies.

Craig T, Zaragoza-Urdaz R, Li H, Yu M, Ren H, Juethner S Allergy Asthma Clin Immunol. 2022; 18(1):85.

PMID: 36153561 PMC: 9508782. DOI: 10.1186/s13223-022-00721-y.

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