The Characteristics of Laboratory Tests at Admission and the Risk Factors for Adverse Clinical Outcomes of Severe and Critical COVID-19 Patients

Overview

Journal BMC Infect Dis

Publisher Biomed Central

Specialty Infectious Diseases

Date 2021 Apr 21

PMID 33879073

Citations 4

Authors

Liulin Wang

Xiaobin Cheng

Qiufen Dong

Chenliang Zhou

Yeming Wang

Bin Song

Weinan Li

Min Wang

Rui Qin

Qi Long

Juan Liu

Jing Li

Dan Li

Gang Li

Yuanming Ba

Affiliations

Soon will be listed here.

Abstract

Background: The current coronavirus disease 2019 (COVID-19) is a public health emergency. In this study, we aimed to evaluate the risk factors for mortality in severe and critical COVID-19 patients.

Methods: We performed a retrospective study of patients diagnosed with severe and critical COVID-19 from four hospitals in Wuhan, China, by evaluating the clinical characteristics and laboratory results, and using Cox proportional hazards model to assess the risk factors involved in disease progression.

Results: In total, 446 patients with COVID-19 were enrolled. The study indicated a high mortality rate (20.2%) in severe and critical COVID-19 patients. At the time of admission, all patients required oxygen therapy, and 52 (12%) required invasive mechanical ventilation, of which 50 (96%) died. The univariate Cox proportional hazards model showed a white blood cell count of more than 10 × 10/L (HR 3.993,95%CI 2.469 to 6.459) that correlated with an increased mortality rate. The multivariable Cox proportional hazards model demonstrated that older age (HR 1.066, 95% CI 1.043 to 1.089) and higher white blood cell count (HR 1.135, 95% CI 1.080 to 1.192) were independent risk factors for determining COVID-19 associated mortality.

Conclusions: COVID-19 is associated with a significant risk of morbidity and mortality in the population. Older age and higher white blood cell count were found to be independent risk factors for mortality.

Citing Articles

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