Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer's Disease

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2021 Apr 19

PMID 33871799

Citations 11

Authors

Md Sahab Uddin

Dewan Md Sumsuzzman

Philippe Jeandet

Tapan Behl

Abdur Rauf

Md Shah Amran

Ghulam Md Ashraf

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD) is one of the crucial causative factors for progressive dementia. Neuropathologically, AD is characterized by the extracellular accumulation of amyloid beta plaques and intracellular neurofibrillary tangles in cortical and limbic regions of the human brain. The circadian system is one of the many affected physiological processes in AD, the dysfunction of which may reflect in the irregularity of the sleep/wake cycle. The interplay of circadian and sleep disturbances inducing AD progression is bidirectional. Sleep-associated pathological alterations are frequently evident in AD. Understanding the interrelation between circadian disruption and AD may allow for earlier identification of AD pathogenesis as well as better suited approaches and potential therapies to combat dementia. In this article, we examine the existing literature related to the molecular mechanisms of the circadian clock and interacting mechanisms of circadian disruption and AD pathogenesis.

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