Autophagy in Human T-Cell Leukemia Virus Type 1 (HTLV-1) Induced Leukemia

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Apr 19

PMID 33869030

Citations 5

Authors

Nicolas Ducasa

Daniel Grasso

Paula Benencio

Daniela L Papademetrio

Mirna Biglione

Fatah Kashanchi

Carolina Berini

Maria Noe Garcia

Affiliations

Soon will be listed here.

Abstract

Viruses play an important role in the development of certain human cancers. They are estimated to contribute 16% to all human cancers. Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus to be discovered and is the etiological agent of adult T-cell leukemia/lymphoma (ATLL), an aggressive T-cell malignancy with poor prognosis. HTLV-1 viral proteins interact with mechanisms and proteins present in host cells for their own benefit, evading the immune system and promoting the establishment of disease. Several viruses manipulate the autophagy pathway to achieve their infective goals, and HTLV-1 is not the exception. HTLV-1 Tax viral protein engages NF-κB and autophagy pathways prone favoring viral replication and T cell transformation. In this review we focus on describing the relationship of HTLV-1 with the autophagy machinery and its implication in the development of ATLL.

Citing Articles

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