» Articles » PMID: 33867953

Effects of Remote Immune Activation on Performance in the 5-Choice Serial Reaction Time Task Following Mild Traumatic Brain Injury in Adolescence

Overview
Specialty Psychology
Date 2021 Apr 19
PMID 33867953
Citations 3
Authors
Affiliations
Soon will be listed here.
Abstract

In adult pre-clinical models, traumatic brain injury (TBI) has been shown to prime microglia, exaggerating the central inflammatory response to an acute immune challenge, worsening depressive-like behavior, and enhancing cognitive deficits. Whether this phenomenon exists following mTBI during adolescence has yet to be explored, with age at injury potentially altering the inflammatory response. Furthermore, to date, studies have predominantly examined hippocampal-dependent learning domains, although pre-frontal cortex-driven functions, including attention, motivation, and impulsivity, are significantly affected by both adolescent TBI and acute inflammatory stimuli. As such, the current study examined the effects of a single acute peripheral dose of LPS (0.33 mg/kg) given in adulthood following mTBI in mid-adolescence in male Sprague-Dawley rats on performance in the 5-choice serial reaction time task (5-CSRTT). Only previously injured animals given LPS showed an increase in omissions and reward collection latency on the 5-CSRTT, with no effect noted in sham animals given LPS. This is suggestive of impaired motivation and a prolonged central inflammatory response to LPS administration in these animals. Indeed, morphological analysis of myeloid cells within the pre-frontal cortex, IBA1 immunohistochemistry, found that injured animals administered LPS had an increase in complexity in IBA1+ve cells, an effect that was seen to a lesser extent in sham animals. These findings suggest that there may be ongoing alterations in the effects of acute inflammatory stimuli that are driven, in part by increased reactivity of microglial cells.

Citing Articles

Neuromechanical Models of Mild Traumatic Brain Injury Conditioned on Reaction Time: A Systematic Review and Meta-Analysis.

Baskaran A, Hoehn R, Rose C J Clin Med. 2025; 13(24.

PMID: 39768571 PMC: 11677630. DOI: 10.3390/jcm13247648.


Inhibition of RtTg neurons reverses methamphetamine-induced attention deficits.

Qu X, Yang P, Zhai R, Xiong Z Acta Neuropathol Commun. 2024; 12(1):179.

PMID: 39578917 PMC: 11585149. DOI: 10.1186/s40478-024-01890-0.


Repeat Closed-Head Injury in Male Rats Impairs Attention but Causes Heterogeneous Outcomes in Multiple Measures of Impulsivity and Glial Pathology.

Vonder Haar C, Wampler S, Bhatia H, Ozga J, Toegel C, Lake A Front Behav Neurosci. 2022; 16:809249.

PMID: 35359588 PMC: 8963781. DOI: 10.3389/fnbeh.2022.809249.


Traumatic Brain Injury: An Age-Dependent View of Post-Traumatic Neuroinflammation and Its Treatment.

Delage C, Taib T, Mamma C, Lerouet D, Besson V Pharmaceutics. 2021; 13(10).

PMID: 34683918 PMC: 8537402. DOI: 10.3390/pharmaceutics13101624.

References
1.
Eyo U, Peng J, Swiatkowski P, Mukherjee A, Bispo A, Wu L . Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus. J Neurosci. 2014; 34(32):10528-40. PMC: 4200107. DOI: 10.1523/JNEUROSCI.0416-14.2014. View

2.
Spear L . The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev. 2000; 24(4):417-63. DOI: 10.1016/s0149-7634(00)00014-2. View

3.
Asinof S, Paine T . The 5-choice serial reaction time task: a task of attention and impulse control for rodents. J Vis Exp. 2014; (90):e51574. PMC: 6592595. DOI: 10.3791/51574. View

4.
Chudasama Y, Passetti F, Rhodes S, Lopian D, Desai A, Robbins T . Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity. Behav Brain Res. 2003; 146(1-2):105-19. DOI: 10.1016/j.bbr.2003.09.020. View

5.
Felger J, Treadway M . Inflammation Effects on Motivation and Motor Activity: Role of Dopamine. Neuropsychopharmacology. 2016; 42(1):216-241. PMC: 5143486. DOI: 10.1038/npp.2016.143. View