Transcranial Direct Current Stimulation for Balance and Gait in Repetitive Mild Traumatic Brain Injury in Rats

Overview

Journal BMC Neurosci

Publisher Biomed Central

Specialty Neurology

Date 2021 Apr 18

PMID 33865318

Citations 8

Authors

Gahee Park

Jee Hyun Suh

Soo Jeong Han

Affiliations

Soon will be listed here.

Abstract

Background: Balance impairment and lack of postural orientation are serious problems in patients with repetitive mild traumatic brain injury (mTBI).

Objective: To investigate whether anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) can improve balance control and gait in repetitive mTBI rat models.

Methods: In this prospective animal study, 65 repetitive mTBI rats were randomly assigned to two groups: the tDCS group and the control group. To create repetitive mTBI model rats, we induced mTBI in the rats for 3 consecutive days. The tDCS group received one session of anodal tDCS over the M1 area 24 h after the third induced mTBI, while the control group did not receive tDCS treatment. Motor-evoked potential (MEP), foot-fault test, and rotarod test were evaluated before mTBI, before tDCS and after tDCS. The Mann-Whitney U test and Wilcoxon signed rank test were used to assess the effects of variables between the two groups.

Results: Anodal tDCS over the M1 area significantly improved the amplitude of MEP in the tDCS group (p = 0.041). In addition, rotarod duration was significantly increased in the tDCS group (p = 0.001). The foot-fault ratio was slightly lower in the tDCS group, however, this was not statistically significant.

Conclusion: Anodal tDCS at the M1 area could significantly improve the amplitude of MEP and balance function in a repetitive mTBI rat model. We expect that anodal tDCS would have the potential to improve balance in patients with repetitive mTBI.

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References

Barth J, Freeman J, Broshek D, Varney R . Acceleration-Deceleration Sport-Related Concussion: The Gravity of It All. J Athl Train. 2003; 36(3):253-256. PMC: 155415. View

Bodnar C, Roberts K, Higgins E, Bachstetter A . A Systematic Review of Closed Head Injury Models of Mild Traumatic Brain Injury in Mice and Rats. J Neurotrauma. 2019; 36(11):1683-1706. PMC: 6555186. DOI: 10.1089/neu.2018.6127. View

Tiwari H, Tripathi A, Mishra D, Kalita J, Misra U . A study of ER stress in rat model of cerebral venous sinus thrombosis. Neurosci Lett. 2015; 589:121-5. DOI: 10.1016/j.neulet.2015.01.038. View

Epperson C, Haga K, Mason G, Sellers E, Gueorguieva R, Zhang W . Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study. Arch Gen Psychiatry. 2002; 59(9):851-8. DOI: 10.1001/archpsyc.59.9.851. View

Degani A, Santos M, Leonard C, Rau T, Patel S, Mohapatra S . The effects of mild traumatic brain injury on postural control. Brain Inj. 2016; 31(1):49-56. DOI: 10.1080/02699052.2016.1225982. View

Hafez Yosephi M, Ehsani F, Zoghi M, Jaberzadeh S . Multi-session anodal tDCS enhances the effects of postural training on balance and postural stability in older adults with high fall risk: Primary motor cortex versus cerebellar stimulation. Brain Stimul. 2018; 11(6):1239-1250. DOI: 10.1016/j.brs.2018.07.044. View

Smith M, Keel J, Greenberg B, Adams L, Schmidt P, Rubinow D . Menstrual cycle effects on cortical excitability. Neurology. 1999; 53(9):2069-72. DOI: 10.1212/wnl.53.9.2069. View

Du X, Li J, Li M, Yang X, Qi Z, Xu B . Research progress on the role of type I vesicular glutamate transporter (VGLUT1) in nervous system diseases. Cell Biosci. 2020; 10:26. PMC: 7057577. DOI: 10.1186/s13578-020-00393-4. View

Batra N, Seres-Mailo J, Hanstock C, Seres P, Khudabux J, Bellavance F . Proton magnetic resonance spectroscopy measurement of brain glutamate levels in premenstrual dysphoric disorder. Biol Psychiatry. 2007; 63(12):1178-84. DOI: 10.1016/j.biopsych.2007.10.007. View

10.

Meehan 3rd W, Mannix R . Pediatric concussions in United States emergency departments in the years 2002 to 2006. J Pediatr. 2010; 157(6):889-93. PMC: 2988879. DOI: 10.1016/j.jpeds.2010.06.040. View

11.

Schatz P, Moser R . Current issues in pediatric sports concussion. Clin Neuropsychol. 2011; 25(6):1042-57. DOI: 10.1080/13854046.2011.556669. View

12.

Wood T, Hsieh K, An R, Ballard R, Sosnoff J . Balance and Gait Alterations Observed More Than 2 Weeks After Concussion: A Systematic Review and Meta-Analysis. Am J Phys Med Rehabil. 2019; 98(7):566-576. DOI: 10.1097/PHM.0000000000001152. View

13.

Laker S . Epidemiology of concussion and mild traumatic brain injury. PM R. 2011; 3(10 Suppl 2):S354-8. DOI: 10.1016/j.pmrj.2011.07.017. View

14.

Kaski D, Dominguez R, Allum J, Bronstein A . Improving gait and balance in patients with leukoaraiosis using transcranial direct current stimulation and physical training: an exploratory study. Neurorehabil Neural Repair. 2013; 27(9):864-71. DOI: 10.1177/1545968313496328. View

15.

Deliagina T, Zelenin P, Beloozerova I, Orlovsky G . Nervous mechanisms controlling body posture. Physiol Behav. 2007; 92(1-2):148-54. DOI: 10.1016/j.physbeh.2007.05.023. View

16.

Cambiaghi M, Velikova S, Gonzalez-Rosa J, Cursi M, Comi G, Leocani L . Brain transcranial direct current stimulation modulates motor excitability in mice. Eur J Neurosci. 2010; 31(4):704-9. DOI: 10.1111/j.1460-9568.2010.07092.x. View

17.

Jacobs J, Horak F . Cortical control of postural responses. J Neural Transm (Vienna). 2007; 114(10):1339-48. PMC: 4382099. DOI: 10.1007/s00702-007-0657-0. View

18.

Maruta J, Mallott J, Sulioti G, Ghajar J, Palacios E, Mukherjee P . Concussion Disrupts Normal Brain White Matter Microstructural Symmetry. Front Neurol. 2020; 11:548220. PMC: 7688463. DOI: 10.3389/fneur.2020.548220. View

19.

Rogers D, Campbell C, Stretton J, Mackay K . Correlation between motor impairment and infarct volume after permanent and transient middle cerebral artery occlusion in the rat. Stroke. 1997; 28(10):2060-5; discussion 2066. DOI: 10.1161/01.str.28.10.2060. View

20.

Parker T, Osternig L, van Donkelaar P, Chou L . Recovery of cognitive and dynamic motor function following concussion. Br J Sports Med. 2007; 41(12):868-73. PMC: 2658976. DOI: 10.1136/bjsm.2006.033761. View