The Prognostic Significance of Survivin Expression in Patients with HNSCC: a Systematic Review and Meta-analysis

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2021 Apr 17

PMID 33863308

Citations 9

Authors

Liu-Qing Zhou

Yao Hu

Hong-Jun Xiao

Affiliations

Soon will be listed here.

Abstract

Background: Survivin has been recently identified as a promising novel therapeutic target and prognostic marker in different types of cancer. Here we conducted a comprehensive meta-analysis to better clarify they the precise prognostic and diagnostic value of survivin in head and neck squamous cell carcinoma (HNSCC).

Methods: Database of PubMed (Medline), Embase, and Web of Science were systematically searched for related published literature up to September 2020. Pooled hazards ratios (HR) and related 95% confidence intervals (CI) were used to estimate the association of survivin expression and survival outcomes in HNSCC patients.

Results: Twenty eight studies with 4891 patients were finally included in this meta-analysis, the pooled analysis indicated that the survivin expression was significantly correlated with poorer overall survival (OS) (HR, 2.02; 95% CI, 1.65-2.47, P < 0.001), and poorer disease-free survival (DFS)/ disease-specific survival (DSS) (HR = 2.03, 95%CI: 1.64-2.52, P < 0.001; HR = 1.92, 95%CI: 1.41-2.60, P < 0.001, receptively). Similar results were observed in subgroup analysis stratified by different cancer types, such as laryngeal squamous cell carcinoma (LSCC) (HR = 1.35, 95%CI: 1.05-1.74, P < 0.001), oral squamous cell carcinomas (OSCC) (HR = 2.45, 95%CI: 1.89-3.17, P < 0.001), nasopharyngeal carcinoma (NPC) (HR = 2.53, 95%CI: 1.76-3.62, P < 0.001) and HNSCC (HR = 1.52, 95%CI: 1.25-1.86, P < 0.001). Furthermore, ethnicity-stratified analysis indicated that survivin was significantly associated with poorer OS among both Asian and Non- Asian HNSCC patients (HR = 2.16, 95%CI: 1.76-2.66; HR = 1.56, 95%CI: 1.33-1.82, respectively).

Conclusions: Our results suggested that survivin is predictors of worse prognosis in HNSCC patients. Hence, survivin is a potential therapeutic target for HNSCC.

Citing Articles

Enhanced computed tomography radiomics predicts solute carrier family 7, member 11 in head and neck squamous cell carcinoma.

Lv J, Meng X, Li Y, Zhang R, Zhao Y, Yang X Front Genet. 2024; 15:1418578.

PMID: 39350768 PMC: 11439659. DOI: 10.3389/fgene.2024.1418578.

CELSR3 is a prognostic marker in HNSCC and correlates with immune cell infiltration in the tumor microenvironment.

Wu Z, Zhu Z, Wu W, Hu S, Cao J, Huang X Eur Arch Otorhinolaryngol. 2024; 281(6):3143-3156.

PMID: 38507078 PMC: 11065926. DOI: 10.1007/s00405-024-08566-4.

Caffeic acid phenethyl ester: Unveiling its potential as a potent apoptosis inducer for combating hypopharyngeal squamous cell carcinoma.

Kim H, Ahn M, Shin J, Choi S, Yu H, Cho S Oncol Rep. 2023; 51(2).

PMID: 38099422 PMC: 10777462. DOI: 10.3892/or.2023.8680.

SLA2 is a prognostic marker in HNSCC and correlates with immune cell infiltration in the tumor microenvironment.

Wu Z, You C, Zhu Z, Wu W, Cao J, Xie Q Eur Arch Otorhinolaryngol. 2023; 281(1):427-440.

PMID: 37688682 PMC: 10764518. DOI: 10.1007/s00405-023-08213-4.

Squamous-columnar junction of Von Ebner's glands may be a significant origin of squamous cell carcinomas in the base of the tongue.

Chen P, Chen X, Chen G, Luo L, Yan Q, Ruan P Front Oncol. 2022; 12:1029404.

PMID: 36465343 PMC: 9709342. DOI: 10.3389/fonc.2022.1029404.

References

Khan Z, Tiwari R, Mulherkar R, Sah N, Prasad G, Shrivastava B . Detection of survivin and p53 in human oral cancer: correlation with clinicopathologic findings. Head Neck. 2009; 31(8):1039-48. DOI: 10.1002/hed.21071. View

Stang A . Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010; 25(9):603-5. DOI: 10.1007/s10654-010-9491-z. View

Lo Muzio L, Farina A, Rubini C, Pezzetti F, Stabellini G, Laino G . Survivin as prognostic factor in squamous cell carcinoma of the oral cavity. Cancer Lett. 2005; 225(1):27-33. DOI: 10.1016/j.canlet.2004.11.024. View

Troiano G, Guida A, Aquino G, Botti G, Losito N, Papagerakis S . Integrative Histologic and Bioinformatics Analysis of BIRC5/Survivin Expression in Oral Squamous Cell Carcinoma. Int J Mol Sci. 2018; 19(9). PMC: 6174346. DOI: 10.3390/ijms19092664. View

Marioni G, Staffieri A, Lionello M, Tealdo G, Staffieri C, Giacomelli L . Relationship between anti-apoptotic proteins survivin and Bcl-2, and response to treatment in patients undergoing post-operative RT for laryngeal cancer: a pilot study. J Oral Pathol Med. 2012; 42(4):339-44. DOI: 10.1111/jop.12020. View

Li D, Gao S, Shen B, Dong P . Effect of apoptotic and proliferative indices, P-glycoprotein and survivin expression on prognosis in laryngeal squamous cell carcinoma. Med Oncol. 2010; 28 Suppl 1:S333-40. DOI: 10.1007/s12032-010-9686-x. View

Farnebo L, Tiefenbock K, Ansell A, Thunell L, Garvin S, Roberg K . Strong expression of survivin is associated with positive response to radiotherapy and improved overall survival in head and neck squamous cell carcinoma patients. Int J Cancer. 2013; 133(8):1994-2003. DOI: 10.1002/ijc.28200. View

Altieri D . Survivin, versatile modulation of cell division and apoptosis in cancer. Oncogene. 2003; 22(53):8581-9. DOI: 10.1038/sj.onc.1207113. View

Su L, Wang Y, Xiao M, Lin Y, Yu L . Up-regulation of survivin in oral squamous cell carcinoma correlates with poor prognosis and chemoresistance. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 110(4):484-91. DOI: 10.1016/j.tripleo.2010.04.009. View

10.

Pickhard A, Grober S, Haug A, Piontek G, Wirth M, Strassen U . Survivin and pAkt as potential prognostic markers in squamous cell carcinoma of the head and neck. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014; 117(6):733-42. DOI: 10.1016/j.oooo.2014.02.005. View

11.

OConnor D, Schechner J, Adida C, Mesri M, Rothermel A, Li F . Control of apoptosis during angiogenesis by survivin expression in endothelial cells. Am J Pathol. 2000; 156(2):393-8. PMC: 1850029. DOI: 10.1016/S0002-9440(10)64742-6. View

12.

Li Y, Hu C, Shao Q, Huang M, Hou J, Xie D . Elevated expressions of survivin and VEGF protein are strong independent predictors of survival in advanced nasopharyngeal carcinoma. J Transl Med. 2008; 6:1. PMC: 2254380. DOI: 10.1186/1479-5876-6-1. View

13.

Wang H, Sun B, Zhu Z, Chang E, To K, Hwang J . Eight-signature classifier for prediction of nasopharyngeal [corrected] carcinoma survival. J Clin Oncol. 2011; 29(34):4516-25. DOI: 10.1200/JCO.2010.33.7741. View

14.

Lyu H, Huang J, He Z, Liu B . Epigenetic mechanism of survivin dysregulation in human cancer. Sci China Life Sci. 2018; 61(7):808-814. PMC: 6050049. DOI: 10.1007/s11427-017-9230-2. View

15.

Jin P, Zheng Z, Lu H, Yan J, Zheng G, Zheng Y . Roles of β-catenin, TCF-4, and survivin in nasopharyngeal carcinoma: correlation with clinicopathological features and prognostic significance. Cancer Cell Int. 2019; 19:48. PMC: 6396483. DOI: 10.1186/s12935-019-0764-7. View

16.

Pizem J, Cor A, Gale N . Survivin expression is a negative prognostic marker in laryngeal squamous cell carcinoma and is associated with p53 accumulation. Histopathology. 2004; 45(2):180-6. DOI: 10.1111/j.1365-2559.2004.01925.x. View

17.

Fiedler M, Weber F, Hautmann M, Haubner F, Reichert T, Klingelhoffer C . Biological predictors of radiosensitivity in head and neck squamous cell carcinoma. Clin Oral Investig. 2017; 22(1):189-200. DOI: 10.1007/s00784-017-2099-x. View

18.

Xiang Y, Yao H, Wang S, Hong M, He J, Cao S . Prognostic value of Survivin and Livin in nasopharyngeal carcinoma. Laryngoscope. 2006; 116(1):126-30. DOI: 10.1097/01.mlg.0000187392.87904.35. View

19.

Marioni G, Ottaviano G, Marchese-Ragona R, Fasanaro E, Tealdo G, Zanotti C . Nuclear survivin expression correlates with endoglin-assessed microvascularisation in laryngeal carcinoma. J Clin Pathol. 2017; 70(12):1033-1037. DOI: 10.1136/jclinpath-2016-204230. View

20.

de Maria S, Pannone G, Bufo P, Santoro A, Serpico R, Metafora S . Survivin gene-expression and splicing isoforms in oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2008; 135(1):107-16. DOI: 10.1007/s00432-008-0433-z. View