Cardiac MRI Structural and Functional Predictors of Left Ventricular Ejection Fraction Recovery Following PVC Catheter Ablation

Overview

Journal Sci Rep

Specialty Science

Date 2021 Apr 16

PMID 33859295

Citations 3

Authors

Jessica Mao

Eric Xie

Ela Chamera

Joao A C Lima

Jonathan Chrispin

Affiliations

Soon will be listed here.

Abstract

Frequent premature ventricular contractions (PVCs) can induce cardiomyopathy (PVC CM). We sought to use cardiac magnetic resonance imaging (CMR) to quantify changes in cardiac structure and function of cardiomyopathy patients following catheter ablation for PVCs. Patients undergoing PVC ablation at the Johns Hopkins Hospital with pre-procedural CMR from 2010 to 2018 were included in this study. CMR Images were analyzed to collect information on cardiac structure and function as well as to quantify scar. Of the total 51 included patients, PVC CM (LVEF < 45%) was observed in 51% (n = 29). Of these, 19 had post-ablation ejection fractions quantified, with 78.9% (n = 15) recovering function. Global longitudinal strain was significantly correlated with LVEF (OR 1.831, p < 0.01) but did not predict recovery of function. RV origin of PVCs was more common in the preserved LVEF group but was also significantly correlated with persistently reduced EF post-ablation in the PVC CM group. Scar burden was not correlated with either cardiac function or post-ablation recovery of function. In this cohort, there were no significant CMR findings to predict subsequent recovery of EF after ablation among those with PVC CM. PVC origin in the RV was associated with persistently reduced LVEF after ablation.

Citing Articles

Risk Factors for PVC Induced Cardiomyopathy and Post-Ablation Left Ventricular Systolic Dysfunction Reversibility: A Systematic Review and Meta-Analysis of Observational Studies.

Zhao D, Chen Q, Zhou Z, Zhao P, Shi J, Yin J Rev Cardiovasc Med. 2024; 25(9):327.

PMID: 39355590 PMC: 11440414. DOI: 10.31083/j.rcm2509327.

Mechanisms and Risk Factors for Premature Ventricular Contraction Induced Cardiomyopathy.

Shen X, Zhu X, Zuo L, Liu X, Qin M Rev Cardiovasc Med. 2024; 24(12):353.

PMID: 39077080 PMC: 11272849. DOI: 10.31083/j.rcm2412353.

Premature Ventricular Contraction-Induced Cardiomyopathy: Contemporary Evidence from Risk Stratification, Pathophysiology, and Management.

Attachaipanich T, Thiravetyan B, Tribuddharat N, Jaroonpipatkul S, Navaravong L J Clin Med. 2024; 13(9).

PMID: 38731164 PMC: 11084868. DOI: 10.3390/jcm13092635.

References

Yokokawa M, Siontis K, Kim H, Stojanovska J, Latchamsetty R, Crawford T . Value of cardiac magnetic resonance imaging and programmed ventricular stimulation in patients with frequent premature ventricular complexes undergoing radiofrequency ablation. Heart Rhythm. 2017; 14(11):1695-1701. DOI: 10.1016/j.hrthm.2017.06.040. View

Carballeira Pol L, Deyell M, Frankel D, Benhayon D, Squara F, Chik W . Ventricular premature depolarization QRS duration as a new marker of risk for the development of ventricular premature depolarization-induced cardiomyopathy. Heart Rhythm. 2013; 11(2):299-306. DOI: 10.1016/j.hrthm.2013.10.055. View

Baman T, Lange D, Ilg K, Gupta S, Liu T, Alguire C . Relationship between burden of premature ventricular complexes and left ventricular function. Heart Rhythm. 2010; 7(7):865-9. DOI: 10.1016/j.hrthm.2010.03.036. View

Mollema S, Delgado V, Bertini M, Antoni M, Boersma E, Holman E . Viability assessment with global left ventricular longitudinal strain predicts recovery of left ventricular function after acute myocardial infarction. Circ Cardiovasc Imaging. 2009; 3(1):15-23. DOI: 10.1161/CIRCIMAGING.108.802785. View

Swat S, Cohen D, Shah S, Lloyd-Jones D, Baldridge A, Freed B . Baseline Longitudinal Strain Predicts Recovery of Left Ventricular Ejection Fraction in Hospitalized Patients With Nonischemic Cardiomyopathy. J Am Heart Assoc. 2018; 7(20):e09841. PMC: 6474980. DOI: 10.1161/JAHA.118.009841. View

Romano S, Judd R, Kim R, Kim H, Klem I, Heitner J . Feature-Tracking Global Longitudinal Strain Predicts Death in a Multicenter Population of Patients With Ischemic and Nonischemic Dilated Cardiomyopathy Incremental to Ejection Fraction and Late Gadolinium Enhancement. JACC Cardiovasc Imaging. 2018; 11(10):1419-1429. PMC: 6043421. DOI: 10.1016/j.jcmg.2017.10.024. View

Kim Y, Park S, Lim H, Pak H, Kim Y, Shim W . Chronic frequent premature ventricular complexes originating from right and non-right ventricular outflow tracts. Int Heart J. 2010; 51(6):388-93. DOI: 10.1536/ihj.51.388. View

Bas H, Baser K, Hoyt J, Yokokawa M, Labounty T, Morady F . Effect of circadian variability in frequency of premature ventricular complexes on left ventricular function. Heart Rhythm. 2015; 13(1):98-102. DOI: 10.1016/j.hrthm.2015.07.038. View

Hasdemir C, Ulucan C, Yavuzgil O, Yuksel A, Kartal Y, Simsek E . Tachycardia-induced cardiomyopathy in patients with idiopathic ventricular arrhythmias: the incidence, clinical and electrophysiologic characteristics, and the predictors. J Cardiovasc Electrophysiol. 2011; 22(6):663-8. DOI: 10.1111/j.1540-8167.2010.01986.x. View

10.

Walters T, Szilagyi J, Alhede C, Sievers R, Fang Q, Olgin J . Dyssynchrony and Fibrosis Persist After Resolution of Cardiomyopathy in a Swine Premature Ventricular Contraction Model. JACC Clin Electrophysiol. 2020; 6(11):1367-1376. DOI: 10.1016/j.jacep.2020.06.020. View

11.

Blaye-Felice M, Hamon D, Sacher F, Pascale P, Rollin A, Duparc A . Premature ventricular contraction-induced cardiomyopathy: Related clinical and electrophysiologic parameters. Heart Rhythm. 2015; 13(1):103-10. DOI: 10.1016/j.hrthm.2015.08.025. View

12.

Yokokawa M, Kim H, Good E, Chugh A, Pelosi Jr F, Alguire C . Relation of symptoms and symptom duration to premature ventricular complex-induced cardiomyopathy. Heart Rhythm. 2011; 9(1):92-5. DOI: 10.1016/j.hrthm.2011.08.015. View

13.

Abate E, Hoogslag G, Antoni M, Nucifora G, Delgado V, Holman E . Value of three-dimensional speckle-tracking longitudinal strain for predicting improvement of left ventricular function after acute myocardial infarction. Am J Cardiol. 2012; 110(7):961-7. DOI: 10.1016/j.amjcard.2012.05.023. View

14.

Hyman M, Mustin D, Supple G, Schaller R, Santangeli P, Arkles J . Class IC antiarrhythmic drugs for suspected premature ventricular contraction-induced cardiomyopathy. Heart Rhythm. 2018; 15(2):159-163. DOI: 10.1016/j.hrthm.2017.12.018. View

15.

Olgun H, Yokokawa M, Baman T, Kim H, Armstrong W, Good E . The role of interpolation in PVC-induced cardiomyopathy. Heart Rhythm. 2011; 8(7):1046-9. DOI: 10.1016/j.hrthm.2011.02.034. View

16.

Abdelhamid M, Samir R . Reversal of premature ventricular complexes induced cardiomyopathy. Influence of concomitant structural heart disease. Indian Heart J. 2018; 70(3):410-415. PMC: 6034082. DOI: 10.1016/j.ihj.2017.08.025. View

17.

El Kadri M, Yokokawa M, Labounty T, Mueller G, Crawford T, Good E . Effect of ablation of frequent premature ventricular complexes on left ventricular function in patients with nonischemic cardiomyopathy. Heart Rhythm. 2014; 12(4):706-13. DOI: 10.1016/j.hrthm.2014.12.017. View

18.

Shanmugam N, Chua T, Ward D . 'Frequent' ventricular bigeminy--a reversible cause of dilated cardiomyopathy. How frequent is 'frequent'?. Eur J Heart Fail. 2006; 8(8):869-73. DOI: 10.1016/j.ejheart.2006.02.011. View

19.

Tan A, Hu Y, Potfay J, Kaszala K, Howren M, Sima A . Impact of ventricular ectopic burden in a premature ventricular contraction-induced cardiomyopathy animal model. Heart Rhythm. 2015; 13(3):755-61. PMC: 4762722. DOI: 10.1016/j.hrthm.2015.11.016. View

20.

Yarlagadda R, Iwai S, Stein K, Markowitz S, Shah B, Cheung J . Reversal of cardiomyopathy in patients with repetitive monomorphic ventricular ectopy originating from the right ventricular outflow tract. Circulation. 2005; 112(8):1092-7. DOI: 10.1161/CIRCULATIONAHA.105.546432. View