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Emerging Cellular and Molecular Mechanisms Underlying Anticancer Indications of Chrysin

Overview
Journal Cancer Cell Int
Publisher Biomed Central
Date 2021 Apr 16
PMID 33858433
Citations 19
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Abstract

Chrysin has been shown to exert several beneficial pharmacological activities. Chrysin has anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and renoprotective as well as gastrointestinal, respiratory, reproductive, ocular, and skin protective effects through modulating signaling pathway involved in apoptosis, oxidative stress, and inflammation. In the current review, we discussed the emerging cellular and molecular mechanisms underlying therapeutic indications of chrysin in various cancers. Online databases comprising Scopus, PubMed, Embase, ProQuest, Science Direct, Web of Science, and the search engine Google Scholar were searched for available and eligible research articles. The search was conducted by using MeSH terms and keywords in title, abstract, and keywords. In conclusion, experimental studies indicated that chrysin could ameliorate cancers of the breast, gastrointestinal tract, liver and hepatocytes, bladder, male and female reproductive systems, choroid, respiratory tract, thyroid, skin, eye, brain, blood cells, leukemia, osteoblast, and lymph. However, more studies are needed to enhance the bioavailability of chrysin and evaluate this agent in clinical trial studies.

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References
1.
Wang Q, Cheng N, Yi W, Peng S, Zou X . Synthesis, nitric oxide release, and α-glucosidase inhibition of nitric oxide donating apigenin and chrysin derivatives. Bioorg Med Chem. 2014; 22(5):1515-21. DOI: 10.1016/j.bmc.2014.01.038. View

2.
Yang X, Zheng X, Cao J, Xiang H, Liu F, Lv Y . 8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK. World J Gastroenterol. 2010; 16(27):3385-93. PMC: 2904884. DOI: 10.3748/wjg.v16.i27.3385. View

3.
Javan Maasomi Z, Pilehvar Soltanahmadi Y, Dadashpour M, Alipour S, Abolhasani S, Zarghami N . Synergistic Anticancer Effects of Silibinin and Chrysin in T47D Breast Cancer Cells. Asian Pac J Cancer Prev. 2017; 18(5):1283-1287. PMC: 5555536. DOI: 10.22034/APJCP.2017.18.5.1283. View

4.
Debnath S, Kanakaraju M, Islam M, Yeeravalli R, Sen D, Das A . In silico design, synthesis and activity of potential drug-like chrysin scaffold-derived selective EGFR inhibitors as anticancer agents. Comput Biol Chem. 2019; 83:107156. DOI: 10.1016/j.compbiolchem.2019.107156. View

5.
Leon I, Cadavid-Vargas J, Tiscornia I, Porro V, Castelli S, Katkar P . Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model. J Biol Inorg Chem. 2015; 20(7):1175-91. DOI: 10.1007/s00775-015-1298-7. View