Glycated Hemoglobin Influence on Periodontal Status, Pathogens and Salivary Interleukins in Type II Diabetic Tunisian Subjects with Chronic Periodontitis

Overview

Journal J Dent Sci

Specialty Dentistry

Date 2021 Apr 15

PMID 33854710

Citations 3

Authors

Asma Kassab

Yosra Ayed

Shadia A Elsayed

Soha Fuad Alqadi

Nora Abdelgawad

Marwa Mrag

Faten Ben Amor

Affiliations

Soon will be listed here.

Abstract

Background/purpose: Studies have shown that there is a possible correlation between the amount of glycated hemoglobin and the periodontal status. The goal of this study was to investigate the relationship between glycated hemoglobin (HbA1c) and the prevalence of gingival pathogens and circulating interleukin levels in type II diabetic Tunisian subjects.

Material And Methods: The research included four groups; 30 healthy subjects (H group), 30 non-diabetic subjects suffering from chronic periodontitis (CP group). Type-II diabetic patients were divided according to HbA1c level into 30 adequately-controlled type-II diabetes subjects (HbA1c ≤ 7 percent (ATIID&CP group)) and 30 inadequately-controlled type-II diabetes subjects and HbA1c > 7 percent (ITIID&CP group). Clinical periodontal condition parameters and assessment of salivary interleukin IL-1beta, IL-6 and IL-10 were assessed. Quantitative Polymerase Chain Reaction used for detection of Subgingival biofilm of periodontal pathogens.

Results: Clinical parameters analyzed were positively associated with HbA1c levels (p < 0.05). were found in 80 percent of ITIID&CP, 65 percent of CP and almost absent in H group. was present in 100 percent of CP, 85 percent of ITIID&CP, 50 percent of ATIID&CP and 3 percent of H group had an equivalent occurrence. While was scarce in ITIID&CP groups, but abundant in the H group. ITIID&CP had the highest IL-6 and IL-1beta/IL-10 ratios.

Conclusion: HBA1c levels affect periodontal status, pathogens and salivary interleukins in Type-II diabetic Tunisians with chronic periodontitis, compared with stable and chronic periodontitis groups and can interact with periodontal infections and increase the inflammatory state.

Citing Articles

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