Plasma Membrane Integrity: Implications for Health and Disease

Overview

Journal BMC Biol

Publisher Biomed Central

Specialty Biology

Date 2021 Apr 14

PMID 33849525

Citations 68

Authors

Dustin A Ammendolia

William M Bement

John H Brumell

Affiliations

Soon will be listed here.

Abstract

Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience plasma membrane damage from a multitude of stressors in the extra- and intra-cellular environment. To avoid lethal consequences, cells are equipped with repair pathways to restore membrane integrity. Here, we assess plasma membrane damage and repair from a whole-body perspective. We highlight the role of tissue-specific stressors in health and disease and examine membrane repair pathways across diverse cell types. Furthermore, we outline the impact of genetic and environmental factors on plasma membrane integrity and how these contribute to disease pathogenesis in different tissues.

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