The Involvement of MicroRNAs in SARS-CoV-2 Infection Comorbid with HIV-Associated Preeclampsia

Overview

Journal Curr Hypertens Rep

Specialty Cardiology & Vascular Diseases

Date 2021 Apr 13

PMID 33847825

Citations 7

Authors

Tashlen Abel

Jagidesa Moodley

Thajasvarie Naicker

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: This review investigated the potential role of microRNAs (miRNAs) in the synergy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, preeclampsia (PE), and human immunodeficiency virus (HIV) infection. Maternal health is a great concern when treating pregnant women fighting this triad of diseases, which is highly prevalent in South Africa. MicroRNAs are involved in fine-tuning of physiological processes. Disruptions to the balance of this minute protein can lead to various physiological changes that are sometimes pathological.

Recent Findings: MicroRNAs have recently been implicated in PE and have been linked to the anti-angiogenic imbalance evident in PE. Recent in silico studies have identified potential host miRNAs with anti-viral properties against SARS-CoV-2 infection. Studies have demonstrated dysregulated expression of several miRNAs in HIV-1 infection along with the ability of HIV-1 to downregulate anti-viral host microRNAs. This review has highlighted the significant gap in literature on the potential of miRNAs in women with HIV-associated PE in synergy with the novel SARS-CoV-2 infection. In addition, this review has provided evidence of the critical role that the epigenetic regulatory mechanism of miRNA plays in viral infections and PE, thereby providing a foundation for further research investigating the potential of therapeutic miRNA development with fewer side-effects for pregnant women.

Citing Articles

MicroRNA-29 differentially mediates preeclampsia-dysregulated cellular responses to cytokines in female and male fetal endothelial cells.

Zhou C, Freel C, Mills O, Yang X, Yan Q, Zheng J J Physiol. 2023; 601(16):3631-3645.

PMID: 37401732 PMC: 10807859. DOI: 10.1113/JP284746.

miRNAs as a Potential Biomarker in the COVID-19 Infection and Complications Course, Severity, and Outcome.

Jankovic M, Nikolic D, Novakovic I, Petrovic B, Lackovic M, Santric-Milicevic M Diagnostics (Basel). 2023; 13(6).

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Vascular Endothelial Growth Factor Receptor 2: Molecular Mechanism and Therapeutic Potential in Preeclampsia Comorbidity with Human Immunodeficiency Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Infections.

Abel T, Moodley J, Khaliq O, Naicker T Int J Mol Sci. 2022; 23(22).

PMID: 36430232 PMC: 9691176. DOI: 10.3390/ijms232213752.

Neuropilin-1 in the pathogenesis of preeclampsia, HIV-1, and SARS-CoV-2 infection: A review.

Naidoo N, Moodley J, Khaliq O, Naicker T Virus Res. 2022; 319:198880.

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MiRNA-SARS-CoV-2 dialogue and prospective anti-COVID-19 therapies.

Panda M, Kalita E, Singh S, Kumar K, Rao A, Prajapati V Life Sci. 2022; 305:120761.

PMID: 35787998 PMC: 9249409. DOI: 10.1016/j.lfs.2022.120761.

References

Inchley C, Sonerud T, Fjaerli H, Nakstad B . Nasal mucosal microRNA expression in children with respiratory syncytial virus infection. BMC Infect Dis. 2015; 15:150. PMC: 4387708. DOI: 10.1186/s12879-015-0878-z. View

Tikellis C, Johnston C, Forbes J, Burns W, Burrell L, Risvanis J . Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy. Hypertension. 2003; 41(3):392-7. DOI: 10.1161/01.HYP.0000060689.38912.CB. View

Sebitloane H, Moodley J, Sartorius B . Associations between HIV, highly active anti-retroviral therapy, and hypertensive disorders of pregnancy among maternal deaths in South Africa 2011-2013. Int J Gynaecol Obstet. 2017; 136(2):195-199. DOI: 10.1002/ijgo.12038. View

Mol B, Roberts C, Thangaratinam S, Magee L, de Groot C, Hofmeyr G . Pre-eclampsia. Lancet. 2015; 387(10022):999-1011. DOI: 10.1016/S0140-6736(15)00070-7. View

Jones D, Baluja M, Graham D, Corbishley A, McDonald J, Malham S . Shedding of SARS-CoV-2 in feces and urine and its potential role in person-to-person transmission and the environment-based spread of COVID-19. Sci Total Environ. 2020; 749:141364. PMC: 7836549. DOI: 10.1016/j.scitotenv.2020.141364. View

Pringle K, Tadros M, Callister R, Lumbers E . The expression and localization of the human placental prorenin/renin-angiotensin system throughout pregnancy: roles in trophoblast invasion and angiogenesis?. Placenta. 2011; 32(12):956-62. DOI: 10.1016/j.placenta.2011.09.020. View

Maharaj N, Phulukdaree A, Nagiah S, Ramkaran P, Tiloke C, Chuturgoon A . Pro-Inflammatory Cytokine Levels in HIV Infected and Uninfected Pregnant Women with and without Preeclampsia. PLoS One. 2017; 12(1):e0170063. PMC: 5240954. DOI: 10.1371/journal.pone.0170063. View

Liang Y, Ridzon D, Wong L, Chen C . Characterization of microRNA expression profiles in normal human tissues. BMC Genomics. 2007; 8:166. PMC: 1904203. DOI: 10.1186/1471-2164-8-166. View

Wang W, Feng L, Zhang H, Hachy S, Satohisa S, Laurent L . Preeclampsia up-regulates angiogenesis-associated microRNA (i.e., miR-17, -20a, and -20b) that target ephrin-B2 and EPHB4 in human placenta. J Clin Endocrinol Metab. 2012; 97(6):E1051-9. PMC: 3387422. DOI: 10.1210/jc.2011-3131. View

10.

Ahluwalia J, Khan S, Soni K, Rawat P, Gupta A, Hariharan M . Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication. Retrovirology. 2008; 5:117. PMC: 2635386. DOI: 10.1186/1742-4690-5-117. View

11.

Shah D . Role of the renin-angiotensin system in the pathogenesis of preeclampsia. Am J Physiol Renal Physiol. 2005; 288(4):F614-25. DOI: 10.1152/ajprenal.00410.2003. View

12.

Valero L, Alhareth K, Gil S, Lecarpentier E, Tsatsaris V, Mignet N . Nanomedicine as a potential approach to empower the new strategies for the treatment of preeclampsia. Drug Discov Today. 2018; 23(5):1099-1107. DOI: 10.1016/j.drudis.2018.01.048. View

13.

Mattar R, Amed A, Lindsey P, Sass N, Daher S . Preeclampsia and HIV infection. Eur J Obstet Gynecol Reprod Biol. 2004; 117(2):240-1. DOI: 10.1016/j.ejogrb.2004.04.014. View

14.

Mostafa-Hedeab G . ACE2 as Drug Target of COVID-19 Virus Treatment, Simplified Updated Review. Rep Biochem Mol Biol. 2020; 9(1):97-105. PMC: 7424417. DOI: 10.29252/rbmb.9.1.97. View

15.

Sun H, Zeng D, Li R, Pang R, Yang H, Hu Y . Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase. Hypertension. 2012; 60(6):1407-14. DOI: 10.1161/HYPERTENSIONAHA.112.197301. View

16.

Mishra R, Kumar A, Ingle H, Kumar H . The Interplay Between Viral-Derived miRNAs and Host Immunity During Infection. Front Immunol. 2020; 10:3079. PMC: 6989438. DOI: 10.3389/fimmu.2019.03079. View

17.

Young B, Levine R, Karumanchi S . Pathogenesis of preeclampsia. Annu Rev Pathol. 2010; 5:173-92. DOI: 10.1146/annurev-pathol-121808-102149. View

18.

Salomon C, Guanzon D, Scholz-Romero K, Longo S, Correa P, Illanes S . Placental Exosomes as Early Biomarker of Preeclampsia: Potential Role of Exosomal MicroRNAs Across Gestation. J Clin Endocrinol Metab. 2017; 102(9):3182-3194. DOI: 10.1210/jc.2017-00672. View

19.

Batlle D, Wysocki J, Satchell K . Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?. Clin Sci (Lond). 2020; 134(5):543-545. DOI: 10.1042/CS20200163. View

20.

Fu G, Ye G, Nadeem L, Ji L, Manchanda T, Wang Y . MicroRNA-376c impairs transforming growth factor-β and nodal signaling to promote trophoblast cell proliferation and invasion. Hypertension. 2013; 61(4):864-72. DOI: 10.1161/HYPERTENSIONAHA.111.203489. View