Contribution of Genomics to the Surgical Management and Study of Oral Cancer

Overview

Journal Ann Surg Oncol

Publisher Springer

Specialty Oncology

Date 2021 Apr 13

PMID 33846893

Citations 11

Authors

Zuzana Saidak

Claire Lailler

Sylvie Testelin

Bruno Chauffert

Florian Clatot

Antoine Galmiche

Affiliations

Soon will be listed here.

Abstract

Background: Oral squamous cell carcinoma (OSCC) is the most frequent type of tumor arising from the oral cavity. Surgery is the cornerstone of the treatment of these cancers. Tumor biology has long been overlooked as an important contributor to the outcome of surgical procedures, but recent studies are challenging this concept. Molecular analyses of tumor DNA or RNA provide a rich source of information about the biology of OSCC.

Methods: We searched for relevant articles using PubMed. We examined in particular the prospect of applying molecular methods for minimally invasive exploration of OSCC biology.

Results: We examined five potential applications of genomics to the surgical management and study of OSCC: i) assessing oral potentially malignant lesions; ii) tumor staging prior to surgery; iii) predicting postoperative risk in locally advanced tumors; iv) measuring minimal residual disease and optimizing the longitudinal monitoring of OSCC; and v) predicting the efficacy of medical treatment.

Conclusions: Genomic information can be harnessed in order to identify new biomarkers that could improve the staging, choice of therapy and management of OSCC. The identification of new biomarkers is awaited for better personalization of the surgical treatment of OSCC.

Citing Articles

The tumor coagulome as a potential biological determinant of postsurgical recurrence of oral squamous cell carcinoma.

Saidak Z, Galmiche A Front Oral Health. 2025; 6:1554739.

PMID: 40065838 PMC: 11891189. DOI: 10.3389/froh.2025.1554739.

The prognostic role of salivary miRNAs in oral squamous cell carcinoma: technical challenges and clinical perspectives.

Romani C, Assoni C, Mattavelli D, Rampinelli V, Piazza C Acta Otorhinolaryngol Ital. 2024; 44(5):279-284.

PMID: 39283255 PMC: 11556778. DOI: 10.14639/0392-100X-N2981.

Effect of genetic profiling on surgical decisions at hereditary colorectal cancer syndromes.

Goudarzi Y, Monirvaghefi K, Aghaei S, Amiri S, Rezaei M, Dehghanitafti A Heliyon. 2024; 10(15):e34375.

PMID: 39145015 PMC: 11320152. DOI: 10.1016/j.heliyon.2024.e34375.

Leveraging technology-driven strategies to untangle omics big data: circumventing roadblocks in clinical facets of oral cancer.

Satish K, Saravanan K, Augustine D, Saraswathy G, S V S, Khan S Front Oncol. 2024; 13:1183766.

PMID: 38234400 PMC: 10792052. DOI: 10.3389/fonc.2023.1183766.

Delving into New Frontiers: assessing ChatGPT's proficiency in revealing uncharted dimensions of general surgery and pinpointing innovations for future advancements.

Lim B, Seth I, Dooreemeah D, Lee C Langenbecks Arch Surg. 2023; 408(1):446.

PMID: 37999815 DOI: 10.1007/s00423-023-03173-z.

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