Is Vitamin K a Treatment Choice for Atypical Femoral Fractures in Patients with Secondary Osteoporosis?

Overview

Journal J Int Med Res

Publisher Sage Publications

Specialty General Medicine

Date 2021 Apr 13

PMID 33845598

Citations 1

Authors

Bingzhang Wang

Jiahao Tang

Sheji Weng

Liang Chen

Zongyi Wu

Zhongjie Xie

Lei Yang

Affiliations

Soon will be listed here.

Abstract

An atypical femoral fracture (AFF) is a rare complication associated with excessive inhibition of osteoclast expression during treatment of osteoporosis. We herein describe a patient who had been treated with alendronate for more than 10 years and subsequently developed an AFF that healed after treatment with vitamin K (VK2). We also discuss the potential beneficial effects of VK2 on the healing of AFFs. A 48-year-old Asian man with secondary osteoporosis was treated with alendronate for more than 10 years. The patient underwent surgical treatment for a complete AFF of the right femur. Six months postoperatively, he complained of pain in his left thigh. X-ray examination revealed an incomplete AFF of the left femoral shaft. He was then treated with VK2. After 4 months of VK2 treatment, the patient reported that the pain in his left thigh had decreased, and follow-up X-ray examination demonstrated healing of the left AFF line. This case report indicates that VK2 may be a potential direction for pharmacological treatment of AFFs in future research.

Citing Articles

Role of Vitamin K in Bone and Muscle Metabolism.

Alonso N, Meinitzer A, Fritz-Petrin E, Enko D, Herrmann M Calcif Tissue Int. 2022; 112(2):178-196.

PMID: 35150288 PMC: 9859868. DOI: 10.1007/s00223-022-00955-3.

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