Carcinoembryonic Antigen (CEA) in the Normal Human Small Intestine: a Light and Electron Microscopic Study

Overview

Journal Gut

Specialty Gastroenterology

Date 1977 Oct 1

PMID 338442

Citations 4

Authors

P Isaacson

M A Judd

Affiliations

Soon will be listed here.

Abstract

An immunoperoxidase method for the demonstration of carcinoembryonic antigen (CEA) in tissues was applied to formalin-fixed paraffin embedded and glutaraldehyde-fixed resin sections of normal human small intestine. CEA could easily be demonstrated coating the surface of the small intestine, lining the crypts, and in goblet cells, indicating its presence there in considerable concentration. At the ultrastructural level CEA was localised in the glycocalyx and in mucin granules of goblet cells but not intracytoplasmically.

Citing Articles

Immunohistochemical detection of carcinoembryonic antigen (CEA) in parotid gland carcinomas. Analysis of 52 cases.

Caselitz J, Jaup T, Seifert G Virchows Arch A Pathol Anat Histol. 1981; 394(1-2):49-60.

PMID: 6278701 DOI: 10.1007/BF00431664.

Carcinoembryonic antigen in endoscopic brush specimens from benign and malignant gastric lesions.

Lindgren J, Sipponen P, Seppala K, TARPILA S, Nordling S, Wahlstrom T Br J Cancer. 1979; 40(6):848-55.

PMID: 393292 PMC: 2010141. DOI: 10.1038/bjc.1979.275.

Purification of human intestinal goblet cell antigen (GOA), its immunohistological demonstration in the intestine and in mucus producing gastrointestinal adenocarcinomas.

Rapp W, Windisch M, Peschke P, WURSTER K Virchows Arch A Pathol Anat Histol. 1979; 382(2):163-77.

PMID: 157605 DOI: 10.1007/BF01102872.

Immunohistochemistry of carcinoembryonic antigen: characterisation of cross-reactions with other glycoproteins.

Isaacson P, Judd M Gut. 1977; 18(10):779-85.

PMID: 73495 PMC: 1411693. DOI: 10.1136/gut.18.10.779.

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