Metabolomics Reveals Sex-specific Metabolic Shifts and Predicts the Duration from Positive to Negative in Non-severe COVID-19 Patients During Recovery Process

Overview

Journal Comput Struct Biotechnol J

Specialty Biotechnology

Date 2021 Apr 12

PMID 33841749

Citations 15

Authors

Hong Zheng

Shengwei Jin

Ting Li

Weiyang Ying

Binyu Ying

Dong Chen

Jie Ning

Chanfan Zheng

Yuping Li

Chen Li

Chengshui Chen

Xiaokun Li

Hongchang Gao

Affiliations

Soon will be listed here.

Abstract

Metabolic profiling in COVID-19 patients has been associated with disease severity, but there is no report on sex-specific metabolic changes in discharged survivors. Herein we used an integrated approach of LC-MS-and GC-MS-based untargeted metabolomics to analyze plasma metabolic characteristics in men and women with non-severe COVID-19 at both acute period and 30 days after discharge. The results demonstrate that metabolic alterations in plasma of COVID-19 patients during the recovery and rehabilitation process were presented in a sex specific manner. Overall, the levels of most metabolites were increased in COVID-19 patients after the cure relative to acute period. The major plasma metabolic changes were identified including fatty acids in men and glycerophosphocholines and carbohydrates in women. In addition, we found that women had shorter length of hospitalization than men and metabolic characteristics may contribute to predict the duration from positive to negative in non-severe COVID-19 patients. Collectively, this study shed light on sex-specific metabolic shifts in non-severe COVID-19 patients during the recovery process, suggesting a sex bias in prognostic and therapeutic evaluations based on metabolic profiling.

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