The Immunomodulatory Effects of Vitamin D Drops in Children with Recurrent Respiratory Tract Infections

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2021 Apr 12

PMID 33841698

Citations 5

Authors

Jianqiu Xiao

Wei He

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the effects of vitamin D drops on immune function in children with recurrent respiratory tract infections (RRTI).

Methods: The clinical data of 119 children with RRTI in our hospital were retrospectively retrieved, and they were divided into group A (n=59, receiving routine treatment) and group B (n=60, receiving vitamin D drops) based on their treatment modality. The clinical efficacy, symptom disappearance time, immune function index, insulin-like growth factor (IGF-1), 25-hydroxyvitamin D [25-(OH)D], serum y-interferon (INF-y), and the number of episodes of respiratory tract infections were compared between the two groups.

Results: The total effective rate of treatment in group B was 96.67%, which was significantly higher than 71.19% in group A (<0.05). Children in group B had shorter time to disappearance of lung rales, cough, and fever than group A (<0.05). Group B had higher IgA, IgG, and IgM levels, higher CD4, CD3 levels and lower CD8 levels as well as higher IGF-1, 25-(OH)D, INF-y levels, and fewer respiratory infections after treatment than group A (<0.05).

Conclusion: Vitamin D drops are effective in the treatment of children with RRTI, which is beneficial to the improvement of clinical symptoms and immune function.

Citing Articles

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The dysfunction of Tfh cells promotes pediatric recurrent respiratory tract infections development by interfering humoral immune responses.

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