CircRNAs As Promising Biomarkers of Inflammatory Bowel Disease and Its Associated-colorectal Cancer

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2021 Apr 12

PMID 33841681

Citations 9

Authors

Yuting Xu

Xinwei Xu

Dickson Kofi Wiredu Ocansey

Hua Cao

Wei Qiu

Qiang Tu

Fei Mao

Affiliations

Soon will be listed here.

Abstract

In recent years, research on the pathogenesis of inflammatory bowel disease (IBD) and its associated-colorectal cancer has been well documented to involve environmental, genetic, immune, and intestinal microbiota factors. Evidence indicates that, regardless of the current high global incidence of IBD with over 3.5 million cases in Europe and North America only, it continues to emerge in newly industrialized countries across Asia, Middle East, and South America. Individuals with IBD have significant increased risk of gastrointestinal and extra-intestinal malignancies, particularly, colorectal cancer (CRC) and lymphomas. Among the significant areas of exploration in IBD and its associated-CRC is the search for effective and reliable diagnostic and prognostic markers, and treatment targets. To this effect, the role of non-coding RNAs in IBD and its associated-CRC has attracted research attention, among which microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) get more detailed exploration while little is known about circular RNAs (circRNAs). This review focuses on the emerging role of circRNAs in the diagnosis, prognosis, and treatment of IBD and its associated-CRC. It introduces the biogenesis of circRNAs and brings an up-to-date report on those found within IBD and CRC environment, as well as their participation toward the promotion or suppression of the conditions, and their diagnostic potentials.

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References

Fujita T, Reis L, Watanabe N, Kimura Y, Taniguchi T, Vilcek J . Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways. Proc Natl Acad Sci U S A. 1989; 86(24):9936-40. PMC: 298617. DOI: 10.1073/pnas.86.24.9936. View

Zhang P, Zuo Z, Shang W, Wu A, Bi R, Wu J . Identification of differentially expressed circular RNAs in human colorectal cancer. Tumour Biol. 2017; 39(3):1010428317694546. DOI: 10.1177/1010428317694546. View

Wang W, Jovel J, Halloran B, Wine E, Patterson J, Ford G . Metagenomic analysis of microbiome in colon tissue from subjects with inflammatory bowel diseases reveals interplay of viruses and bacteria. Inflamm Bowel Dis. 2015; 21(6):1419-27. PMC: 4450971. DOI: 10.1097/MIB.0000000000000344. View

Kim H, Lee S, Gardiner A, Perrone-Bizzozero N, Yoo S . Different motif requirements for the localization zipcode element of β-actin mRNA binding by HuD and ZBP1. Nucleic Acids Res. 2015; 43(15):7432-46. PMC: 4551932. DOI: 10.1093/nar/gkv699. View

He C, Yu T, Shi Y, Ma C, Yang W, Fang L . MicroRNA 301A Promotes Intestinal Inflammation and Colitis-Associated Cancer Development by Inhibiting BTG1. Gastroenterology. 2017; 152(6):1434-1448.e15. DOI: 10.1053/j.gastro.2017.01.049. View

Luo Z, Rong Z, Zhang J, Zhu Z, Yu Z, Li T . Circular RNA circCCDC9 acts as a miR-6792-3p sponge to suppress the progression of gastric cancer through regulating CAV1 expression. Mol Cancer. 2020; 19(1):86. PMC: 7210689. DOI: 10.1186/s12943-020-01203-8. View

Mukherjee N, Corcoran D, Nusbaum J, Reid D, Georgiev S, Hafner M . Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability. Mol Cell. 2011; 43(3):327-39. PMC: 3220597. DOI: 10.1016/j.molcel.2011.06.007. View

Zeng K, Chen X, Xu M, Liu X, Hu X, Xu T . CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7. Cell Death Dis. 2018; 9(4):417. PMC: 5856798. DOI: 10.1038/s41419-018-0454-8. View

Chaleshi V, Irani S, Alebouyeh M, Mirfakhraie R, Aghdaei H . Association of lncRNA-p53 regulatory network (lincRNA-p21, lincRNA-ROR and MALAT1) and p53 with the clinicopathological features of colorectal primary lesions and tumors. Oncol Lett. 2020; 19(6):3937-3949. PMC: 7204634. DOI: 10.3892/ol.2020.11518. View

10.

Du W, Zhang C, Yang W, Yong T, Awan F, Yang B . Identifying and Characterizing circRNA-Protein Interaction. Theranostics. 2017; 7(17):4183-4191. PMC: 5695005. DOI: 10.7150/thno.21299. View

11.

Fernandes M, Verstraete S, Phan T, Deng X, Stekol E, LaMere B . Enteric Virome and Bacterial Microbiota in Children With Ulcerative Colitis and Crohn Disease. J Pediatr Gastroenterol Nutr. 2018; 68(1):30-36. PMC: 6310095. DOI: 10.1097/MPG.0000000000002140. View

12.

Suzuki H, Tsukahara T . A view of pre-mRNA splicing from RNase R resistant RNAs. Int J Mol Sci. 2014; 15(6):9331-42. PMC: 4100097. DOI: 10.3390/ijms15069331. View

13.

Ju H, Zhao Q, Wang F, Lan P, Wang Z, Zuo Z . A circRNA signature predicts postoperative recurrence in stage II/III colon cancer. EMBO Mol Med. 2019; 11(10):e10168. PMC: 6783650. DOI: 10.15252/emmm.201810168. View

14.

Xu H, Wang C, Song H, Xu Y, Ji G . RNA-Seq profiling of circular RNAs in human colorectal Cancer liver metastasis and the potential biomarkers. Mol Cancer. 2019; 18(1):8. PMC: 6327571. DOI: 10.1186/s12943-018-0932-8. View

15.

Loftus Jr E . Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology. 2004; 126(6):1504-17. DOI: 10.1053/j.gastro.2004.01.063. View

16.

Vrablicova Z, Soltys K, Krajcovicova A, Stuchlikova K, Sturdik I, Koller T . Impact of smoking cigarette on the mRNA expression of cytokines in mucosa of inflammatory bowel disease. Physiol Res. 2019; 68(Suppl 2):S183-S192. DOI: 10.33549/physiolres.934301. View

17.

Lopez-Siles M, Aldeguer X, Sabat-Mir M, Serra-Pages M, Duncan S, Flint H . Evaluation of bacterial biomarkers to aid in challenging inflammatory bowel diseases diagnostics and subtype classification. World J Gastrointest Pathophysiol. 2020; 11(3):64-77. PMC: 7226914. DOI: 10.4291/wjgp.v11.i3.64. View

18.

Wang T, Chen N, Ren W, Liu F, Gao F, Ye L . Integrated analysis of circRNAs and mRNAs expression profile revealed the involvement of hsa_circ_0007919 in the pathogenesis of ulcerative colitis. J Gastroenterol. 2019; 54(9):804-818. DOI: 10.1007/s00535-019-01585-7. View

19.

Lin S, Song S, Sun R, Zhang M, Du Y, Zhang D . Oncogenic circular RNA Hsa-circ-000684 interacts with microRNA-186 to upregulate ZEB1 in gastric cancer. FASEB J. 2020; 34(6):8187-8203. DOI: 10.1096/fj.201903246R. View

20.

Fritsch J, Garces L, Quintero M, Pignac-Kobinger J, Santander A, Fernandez I . Low-Fat, High-Fiber Diet Reduces Markers of Inflammation and Dysbiosis and Improves Quality of Life in Patients With Ulcerative Colitis. Clin Gastroenterol Hepatol. 2020; 19(6):1189-1199.e30. DOI: 10.1016/j.cgh.2020.05.026. View