Alpha 2.0
Login Register
» Articles » PMID: 33841388

New Thio-Compounds and Monoterpenes With Anti-inflammatory Activities From the Fungus Sp. CYH26

Overview
Journal Front Microbiol
Specialty Microbiology
Date 2021 Apr 12
PMID 33841388
Citations 4
Authors
Guojun Pan
Yanling Li
Xinyu Che
Dan Tian
Wenjie Han
Zimin Wang
Yanfen Zhao
Shuang Ren
Yiru Xu
Gangping Hao
Mengfei Guo
Na Xiao
Fandong Kong
Affiliations
Soon will be listed here.
Abstract

Two new thio-compounds named aspergerthinol A and B ( and ) and two new monoterpenes named aspergerthinacids A and B ( and ) were isolated from the fungus sp. CYH26 from the rhizosphere soil of Decne. The structures of compounds were elucidated by spectroscopic data and quantum NMR and ECD calculations. Compounds and represented a new family of sulfur containing natural products with a 3-methyl-4-cyclopenta[b]thiophen-4-one skeleton. Compounds showed inhibitory activities against nitric oxide (NO) with IC values of 38.0, 19.8, 46.3, and 56.6 μM, respectively.

Citing Articles

Exploration of diverse secondary metabolites from Penicillium brasilianum by co-culturing with Armillaria mellea.

Rong X, Zhang L, He W, Guo Z, Lv H, Bai J Appl Microbiol Biotechnol. 2024; 108(1):462.

PMID: 39264460 PMC: 11393291. DOI: 10.1007/s00253-024-13282-4.

Prenylated indole-terpenoids with antidiabetic activities from sp. HFF16 from the rhizosphere soil of Decne.

Liu X, Kong F, Xiao N, Li X, Zhang M, Lv F Front Microbiol. 2023; 14:1099103.

PMID: 36937284 PMC: 10018213. DOI: 10.3389/fmicb.2023.1099103.

Anti-Diabetic Indole-Terpenoids From sp. HFF16 Isolated From the Rhizosphere Soil of Decne.

Xiao N, Xu Y, Zhang X, Li H, Zhang S, Xiao A Front Chem. 2022; 9:792810.

PMID: 35211458 PMC: 8861352. DOI: 10.3389/fchem.2021.792810.

Indole-Terpenoids With Anti-inflammatory Activities From sp. HFF16 Associated With the Rhizosphere Soil of Decne.

Pan G, Zhao Y, Ren S, Liu F, Xu Q, Pan W Front Microbiol. 2021; 12:710364.

PMID: 34305878 PMC: 8302409. DOI: 10.3389/fmicb.2021.710364.

References
1.
Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J . Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2018; 9(6):7204-7218. PMC: 5805548. DOI: 10.18632/oncotarget.23208. View
2.
Lv Q, Fan Y, Tao G, Fu P, Zhai J, Ye B . Sekgranaticin, a SEK34b-Granaticin Hybrid Polyketide from sp. 166. J Org Chem. 2019; 84(14):9087-9092. DOI: 10.1021/acs.joc.9b01022. View
3.
Keller N . Fungal secondary metabolism: regulation, function and drug discovery. Nat Rev Microbiol. 2018; 17(3):167-180. PMC: 6381595. DOI: 10.1038/s41579-018-0121-1. View
4.
Kong F, Fan P, Zhou L, Ma Q, Xie Q, Zheng H . Penerpenes A-D, Four Indole Terpenoids with Potent Protein Tyrosine Phosphatase Inhibitory Activity from the Marine-Derived Fungus Penicillium sp. KFD28. Org Lett. 2019; 21(12):4864-4867. DOI: 10.1021/acs.orglett.9b01751. View
5.
Qadri M, Johri S, Shah B, Khajuria A, Sidiq T, Lattoo S . Identification and bioactive potential of endophytic fungi isolated from selected plants of the Western Himalayas. Springerplus. 2013; 2(1):8. PMC: 3568471. DOI: 10.1186/2193-1801-2-8. View