Alteration of Diffusion Capacity After SARS-CoV-2 Infection: A Pathophysiological Approach

Overview

Journal Front Physiol

Date 2021 Apr 12

PMID 33841169

Citations 6

Authors

Justine Frija-Masson

Catherine Bancal

Laurent Plantier

Helene Benzaquen

Laurence Mangin

Dominique Penaud

Florence Arnoult

Martin Flamant

Marie-Pia dOrtho

Affiliations

Soon will be listed here.

Abstract

Severe acute respiratory syndrome coronavirus 2 (--) infection has affected millions of people worldwide, and pneumonia affects 90% of patients. This raises the possibility of millions of people with altered lung function. Few data exist to date on pulmonary function after SARS-CoV-2 infection, but alteration of diffusion capacity of CO ( ) is the most frequently described abnormality. First, we present original data on lung function at 3 months after SARS-CoV-2 infection and discuss the effect of using European Coal and Steel Community (ECSC) or Global Lung Function Initiative (GLI) reference equations to diagnose diffusion capacity. Second, we review existing data on alteration after SARS-CoV-2 infection and discuss the implication of restrictive disorder in alteration. Last, we discuss the pathophysiology of alteration and try to disentangle vascular damage and fibrosis.

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References

Gaertner F, Massberg S . Blood coagulation in immunothrombosis-At the frontline of intravascular immunity. Semin Immunol. 2016; 28(6):561-569. DOI: 10.1016/j.smim.2016.10.010. View

Johnson D . Importance of adjusting carbon monoxide diffusing capacity (DLCO) and carbon monoxide transfer coefficient (KCO) for alveolar volume. Respir Med. 2000; 94(1):28-37. DOI: 10.1053/rmed.1999.0740. View

Schwensen H, Borreschmidt L, Storgaard M, Redsted S, Christensen S, Madsen L . Fatal pulmonary fibrosis: a post-COVID-19 autopsy case. J Clin Pathol. 2020; . DOI: 10.1136/jclinpath-2020-206879. View

Radermecker C, Detrembleur N, Guiot J, Cavalier E, Henket M, DEmal C . Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19. J Exp Med. 2020; 217(12). PMC: 7488867. DOI: 10.1084/jem.20201012. View

Evans P, Rainger G, Mason J, Guzik T, Osto E, Stamataki Z . Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science. Cardiovasc Res. 2020; 116(14):2177-2184. PMC: 7454368. DOI: 10.1093/cvr/cvaa230. View

Eapen M, Lu W, Gaikwad A, Bhattarai P, Chia C, Hardikar A . Endothelial to mesenchymal transition: a precursor to post-COVID-19 interstitial pulmonary fibrosis and vascular obliteration?. Eur Respir J. 2020; 56(4). PMC: 7453738. DOI: 10.1183/13993003.03167-2020. View

Zhao Y, Shang Y, Song W, Li Q, Xie H, Xu Q . Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery. EClinicalMedicine. 2020; 25:100463. PMC: 7361108. DOI: 10.1016/j.eclinm.2020.100463. View

Revel M, Parkar A, Prosch H, Silva M, Sverzellati N, Gleeson F . COVID-19 patients and the radiology department - advice from the European Society of Radiology (ESR) and the European Society of Thoracic Imaging (ESTI). Eur Radiol. 2020; 30(9):4903-4909. PMC: 7170031. DOI: 10.1007/s00330-020-06865-y. View

Brazzale D, Seccombe L, Welsh L, Lanteri C, Farah C, Ruehland W . Effects of adopting the Global Lung Function Initiative 2017 reference equations on the interpretation of carbon monoxide transfer factor. Eur Respir J. 2020; 55(5). DOI: 10.1183/13993003.01905-2019. View

10.

Patel K, Straudi S, Yee Sien N, Fayed N, Melvin J, Sivan M . Applying the WHO ICF Framework to the Outcome Measures Used in the Evaluation of Long-Term Clinical Outcomes in Coronavirus Outbreaks. Int J Environ Res Public Health. 2020; 17(18). PMC: 7558385. DOI: 10.3390/ijerph17186476. View

11.

Qian S, Hong W, Lingjie-Mao , Chenfeng-Lin , Zhendong-Fang , Pan J . Clinical Characteristics and Outcomes of Severe and Critical Patients With 2019 Novel Coronavirus Disease (COVID-19) in Wenzhou: A Retrospective Study. Front Med (Lausanne). 2020; 7:552002. PMC: 7500473. DOI: 10.3389/fmed.2020.552002. View

12.

Andrejak C, Blanc F, Costes F, Crestani B, Debieuvre D, Perez T . [Guide for follow-up of patients with SARS-CoV-2 pneumonia. Management proposals developed by the French-language Respiratory Medicine Society. Version of 10 May 2020]. Rev Mal Respir. 2020; 37(6):505-510. PMC: 7221358. DOI: 10.1016/j.rmr.2020.05.001. View

13.

Goertz Y, Van Herck M, Delbressine J, Vaes A, Meys R, Machado F . Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome?. ERJ Open Res. 2020; 6(4). PMC: 7491255. DOI: 10.1183/23120541.00542-2020. View

14.

George P, Barratt S, Condliffe R, Desai S, Devaraj A, Forrest I . Respiratory follow-up of patients with COVID-19 pneumonia. Thorax. 2020; 75(11):1009-1016. DOI: 10.1136/thoraxjnl-2020-215314. View

15.

Petrof B . Diaphragm Weakness in the Critically Ill: Basic Mechanisms Reveal Therapeutic Opportunities. Chest. 2018; 154(6):1395-1403. DOI: 10.1016/j.chest.2018.08.1028. View

16.

Slutsky A, Ranieri V . Ventilator-induced lung injury. N Engl J Med. 2013; 369(22):2126-36. DOI: 10.1056/NEJMra1208707. View

17.

Bhatt S, Balte P, Schwartz J, Cassano P, Couper D, Jacobs Jr D . Discriminative Accuracy of FEV1:FVC Thresholds for COPD-Related Hospitalization and Mortality. JAMA. 2019; 321(24):2438-2447. PMC: 6593636. DOI: 10.1001/jama.2019.7233. View

18.

Combet M, Pavot A, Savale L, Humbert M, Monnet X . Rapid onset honeycombing fibrosis in spontaneously breathing patient with COVID-19. Eur Respir J. 2020; 56(2). PMC: 7338404. DOI: 10.1183/13993003.01808-2020. View

19.

Wapenaar M, Miedema J, Lammering C, Mertens F, Wijsenbeek M . The impact of the new Global Lung Function Initiative reference values on trial inclusion for patients with idiopathic pulmonary fibrosis. Eur Respir J. 2019; 53(2). DOI: 10.1183/13993003.01895-2018. View

20.

Klok F, Boon G, Barco S, Endres M, Geelhoed J, Knauss S . The Post-COVID-19 Functional Status scale: a tool to measure functional status over time after COVID-19. Eur Respir J. 2020; 56(1). PMC: 7236834. DOI: 10.1183/13993003.01494-2020. View