» Articles » PMID: 33838029

A Spatiotemporal Recommendation Engine for Malaria Control

Overview
Journal Biostatistics
Specialty Public Health
Date 2021 Apr 10
PMID 33838029
Citations 3
Authors
Affiliations
Soon will be listed here.
Abstract

Malaria is an infectious disease affecting a large population across the world, and interventions need to be efficiently applied to reduce the burden of malaria. We develop a framework to help policy-makers decide how to allocate limited resources in realtime for malaria control. We formalize a policy for the resource allocation as a sequence of decisions, one per intervention decision, that map up-to-date disease related information to a resource allocation. An optimal policy must control the spread of the disease while being interpretable and viewed as equitable to stakeholders. We construct an interpretable class of resource allocation policies that can accommodate allocation of resources residing in a continuous domain and combine a hierarchical Bayesian spatiotemporal model for disease transmission with a policy-search algorithm to estimate an optimal policy for resource allocation within the pre-specified class. The estimated optimal policy under the proposed framework improves the cumulative long-term outcome compared with naive approaches in both simulation experiments and application to malaria interventions in the Democratic Republic of the Congo.

Citing Articles

A Bayesian Spatio-temporal Model to Optimize Allocation of Buprenorphine in North Carolina.

Dong Q, Kline D, Hepler S Stat Public Policy (Phila). 2023; 10(1).

PMID: 37545670 PMC: 10398789. DOI: 10.1080/2330443x.2023.2218448.


A Review of Spatial Causal Inference Methods for Environmental and Epidemiological Applications.

Reich B, Yang S, Guan Y, Giffin A, Miller M, Rappold A Int Stat Rev. 2023; 89(3):605-634.

PMID: 37197445 PMC: 10187770. DOI: 10.1111/insr.12452.


Estimating optimal dynamic treatment strategies under resource constraints using dynamic marginal structural models.

Caniglia E, Murray E, Hernan M, Shahn Z Stat Med. 2021; 40(23):4996-5005.

PMID: 34184763 PMC: 9017598. DOI: 10.1002/sim.9107.

References
1.
Okell L, Cairns M, Griffin J, Ferguson N, Tarning J, Jagoe G . Contrasting benefits of different artemisinin combination therapies as first-line malaria treatments using model-based cost-effectiveness analysis. Nat Commun. 2014; 5:5606. PMC: 4263185. DOI: 10.1038/ncomms6606. View

2.
Nord E . Cost-value analysis of health interventions: introduction and update on methods and preference data. Pharmacoeconomics. 2014; 33(2):89-95. DOI: 10.1007/s40273-014-0212-4. View

3.
Zhao Y, Zeng D, Laber E, Kosorok M . New Statistical Learning Methods for Estimating Optimal Dynamic Treatment Regimes. J Am Stat Assoc. 2015; 110(510):583-598. PMC: 4517946. DOI: 10.1080/01621459.2014.937488. View

4.
Kang S, Battle K, Gibson H, Ratsimbasoa A, Randrianarivelojosia M, Ramboarina S . Spatio-temporal mapping of Madagascar's Malaria Indicator Survey results to assess Plasmodium falciparum endemicity trends between 2011 and 2016. BMC Med. 2018; 16(1):71. PMC: 5964908. DOI: 10.1186/s12916-018-1060-4. View

5.
Chen G, Zeng D, Kosorok M . Personalized Dose Finding Using Outcome Weighted Learning. J Am Stat Assoc. 2017; 111(516):1509-1521. PMC: 5327863. DOI: 10.1080/01621459.2016.1148611. View