Roles of Microglial Membranes in Alzheimer's Disease

Overview

Journal Curr Top Membr

Specialties Biochemistry
Cell Biology

Date 2021 Apr 10

PMID 33837697

Citations 2

Authors

Jae-Won Shin

James C Lee

Affiliations

Soon will be listed here.

Abstract

The majority of Alzheimer's disease (AD) risk genes are highly and selectively expressed by microglia in the brain. Several of these genes are related to lipid and cholesterol metabolism, lipid synthesis, lipid transport, endocytosis, exocytosis and phagocytosis. Therefore, studying the roles of cellular membrane biophysics in microglial function should improve our understanding of the AD pathology. In this chapter, we discuss how lipid rafts and membrane-cytoskeleton adhesion impact microglial-mediated oxidative stress and clearance of amyloid-β peptide (Aβ). We also discuss potential roles of lipid membrane-bound extracellular vesicles as carriers of pathological factors to promote inflammation and cytotoxicity.

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