The Risk of Pulmonary Tuberculosis After Traumatic Brain Injury

Overview

Journal Sci Rep

Specialty Science

Date 2021 Apr 10

PMID 33837282

Citations 1

Authors

Hsin-Yueh Liu

Kuang-Ming Liao

Fu-Wen Liang

Yi-Chieh Hung

Jhi-Joung Wang

Te-Chun Shen

Chung-Han Ho

Affiliations

Soon will be listed here.

Abstract

After traumatic brain injury (TBI), an inflammatory response in the brain might affect the immune system. The risk of pulmonary infection reportedly increases in patients with TBI. We aimed to evaluate the risk of tuberculosis (TB) in patients with TBI in Taiwan. All participants were selected from the intensive care unit (ICU). Patients with TBI were defined as patients in ICU with intracranial injury, and comparison cohort were patients in ICU without TBI diagnosis. There was a significant difference in TB risk between the patients with TBI and the comparison cohort according to age and the Charlson's comorbidity index (CCI) score. Thus, we divided patients based on CCI into three groups for further analysis: mild (CCI = 0), moderate (CCI = 1/2), severe (CCI > 2). Mild-CCI group had a lower TB incidence rate (0.74%) and longer time to TB development (median: 2.43) than the other two groups. Moderate-CCI group had 1.52-fold increased risk of TB infection (p < 0.0001) compared with mild-CCI group. In the severe-CCI group, patients aged ≥ 80 years had 1.91-fold risk of TB compared with mild-CCI group (p = 0.0481). Severe-CCI group had significantly higher mortality than the mild-CCI group (p = 0.0366). Patients with TBI and more comorbidities had higher risk of TB infection with higher mortality rate.

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PMID: 37157929 PMC: 10314107. DOI: 10.1111/cns.14247.

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