Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis

Overview

Journal Front Physiol

Date 2021 Apr 9

PMID 33833689

Citations 4

Authors

Ruben Coronel

Mark Potse

Michel Haissaguerre

Nicolas Derval

Mathilde R Rivaud

Veronique M F Meijborg

Matthijs Cluitmans

Meleze Hocini

Bastiaan J Boukens

Affiliations

Soon will be listed here.

Abstract

Ablation of sites showing Purkinje activity is antiarrhythmic in some patients with idiopathic ventricular fibrillation (iVF). The mechanism for the therapeutic success of ablation is not fully understood. We propose that deeper penetrance of the Purkinje network allows faster activation of the ventricles and is proarrhythmic in the presence of steep repolarization gradients. Reduction of Purkinje penetrance, or its indirect reducing effect on apparent propagation velocity may be a therapeutic target in patients with iVF.

Citing Articles

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