A NSQIP-based Randomized Clinical Trial Evaluating Choice of Prophylactic Antibiotics for Pancreaticoduodenectomy

Overview

Journal J Surg Oncol

Specialties General Surgery
Oncology

Date 2021 Apr 8

PMID 33831250

Citations 3

Authors

Brian C Brajcich

Clifford Y Ko

Jason B Liu

Ryan J Ellis

Michael I D Angelica

Affiliations

Soon will be listed here.

Abstract

Surgical site infection after pancreaticoduodenectomy is often caused by pathogens resistant to standard prophylactic antibiotics, suggesting that broad-spectrum antibiotics may be more effective prophylactic agents. This article describes the rationale and methodology underlying a multicenter randomized trial evaluating piperacillin-tazobactam compared with cefoxitin for surgical site infection prevention following pancreaticoduodenectomy. As the first US randomized surgical trial to utilize a clinical registry for data collection, this study serves as proof of concept for registry-based clinical trials.

Citing Articles

Association Between Biliary Pathogens, Surgical Site Infection, and Pancreatic Fistula: Results of a Randomized Trial of Perioperative Antibiotic Prophylaxis in Patients Undergoing Pancreatoduodenectomy.

Ellis R, Brajcich B, Bertens K, Chan C, Fernandez-Del Castillo C, Karanicolas P Ann Surg. 2023; 278(3):310-319.

PMID: 37314221 PMC: 10838195. DOI: 10.1097/SLA.0000000000005955.

How Does Medical Policy on the Use of Prophylactic Antibiotics Affect Medical Costs, Length of Hospital Stay, and Antibiotic Use in Orthopedics?.

Kim S, Jang S, Cha Y, Kim B, Lee H, Kim G Yonsei Med J. 2023; 64(3):213-220.

PMID: 36825348 PMC: 9971434. DOI: 10.3349/ymj.2022.0546.

Impact of Extended Antibiotic Use After Pancreaticoduodenectomy for Patients with Preoperative Metallic Biliary Stenting Treated with Neoadjuvant Chemotherapy.

Hammad A, Khachfe H, AlMasri S, Desilva A, Liu H, Nassour I J Gastrointest Surg. 2023; 27(4):716-723.

PMID: 36650416 PMC: 11234506. DOI: 10.1007/s11605-023-05581-4.

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