The Trophocytes and Oenocytes of Worker and Queen Honey Bees (Apis Mellifera) Exhibit Distinct Age-associated Transcriptome Profiles

Overview

Journal Geroscience

Specialty Geriatrics

Date 2021 Apr 7

PMID 33826033

Citations 1

Authors

Cheng-Yen Lu

Yu-Ting Weng

Bertrand Tan

Chin-Yuan Hsu

Affiliations

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Abstract

Despite the identical genomic context, trophocytes and oenocytes in worker bees exhibit aging-related phenotypes, in contrast to the longevity phenotypes in queen bees. To explore this phenomenon at the molecular level, we evaluated the age-associated transcriptomes of trophocytes and oenocytes in worker bees and queen bees using high-throughput RNA-sequencing technology (RNA-seq). The results showed that (i) while gene expression profiles were different between worker and queen bees, they remained similar between young and old counterparts; (ii) worker bees express a high proportion of low-abundance genes, whereas queen bee transcriptomes display a high proportion of moderate-expression genes; (iii) genes were upregulated to a greater extent in queen bees vs. worker bees; and (iv) distinct aging-related and longevity-related candidate genes were found in worker and queen bees. These results provide new insights into the cellular aging and longevity of trophocytes and oenocytes in honey bees. Identification of aging-associated biomarker genes also constitutes a basis for translational research of aging in higher organisms.

Citing Articles

Long-term inhibition of ferritin2 synthesis in trophocytes and oenocytes by ferritin2 double-stranded RNA ingestion to investigate the mechanisms of magnetoreception in honey bees (Apis mellifera).

Hsu C, Weng Y PLoS One. 2021; 16(8):e0256341.

PMID: 34411154 PMC: 8376008. DOI: 10.1371/journal.pone.0256341.

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