Genetic Variants Are Associated with the Susceptibility to Cervical Cancer in a Chinese Population

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2021 Apr 7

PMID 33824876

Authors

Jingjing Chen

Yuanfang Xu

Hongyuan Hu

Tianbo Jin

Affiliations

Soon will be listed here.

Abstract

Background: Cervical cancer (CC) is the second most common tumor in women worldwide. Studies have been accepted that genetic variations play an important role in the development of CC. The aim of this study was to evaluate the impact of variants on CC risk.

Methods: 508 patients of cervical cancer and 497 healthy subjects were recruited to determine the impact of polymorphisms on CC susceptibility. The associations were investigated by computing odds ratios (ORs) and 95% confidence intervals. The effect of SNP-SNP interactions on CC risk was explored by multifactor dimensionality reduction analysis.

Results: Our study showed that rs11904127 (OR 0.79, = 0.010) and rs62162674 (OR 0.82, = 0.044) of significantly decreased cervical cancer risk. Stratified analysis indicated that rs11904127 and rs62162674 present decreased susceptibility to CC in age > 51 years (OR 0.74, = 0.019; OR 0.72, = 0.014, respectively). Haplotype analyses revealed that GTC has a lower risk to cervical cancer (OR = 0.43, = 0.018). Besides, there is strong interaction of rs11904127 and rs2366264.

Conclusion: Rs11904127 and rs62162674 in are related to cervical cancer. We suggest that these variants can be used as prognostic markers for judging the susceptibility to cervical cancer.

References

Zhou F, He X, Liu H, Zhu Y, Jin T, Chen C . Functional polymorphisms of circadian positive feedback regulation genes and clinical outcome of Chinese patients with resected colorectal cancer. Cancer. 2011; 118(4):937-46. DOI: 10.1002/cncr.26348. View

Ricci F, Fratelli M, Guffanti F, Porcu L, Spriano F, DellAnna T . Patient-derived ovarian cancer xenografts re-growing after a cisplatinum treatment are less responsive to a second drug re-challenge: a new experimental setting to study response to therapy. Oncotarget. 2016; 8(5):7441-7451. PMC: 5352333. DOI: 10.18632/oncotarget.7465. View

Wang S, Bratti M, Rodriguez A, Herrero R, Burk R, Porras C . Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer. J Infect Dis. 2008; 199(1):20-30. PMC: 3690375. DOI: 10.1086/595563. View

Niwa Y, Matsuo K, Ito H, Hirose K, Tajima K, Nakanishi T . Association of XRCC1 Arg399Gln and OGG1 Ser326Cys polymorphisms with the risk of cervical cancer in Japanese subjects. Gynecol Oncol. 2005; 99(1):43-9. DOI: 10.1016/j.ygyno.2005.05.018. View

Patel D, Chaudhary J . Increased expression of bHLH transcription factor E2A (TCF3) in prostate cancer promotes proliferation and confers resistance to doxorubicin induced apoptosis. Biochem Biophys Res Commun. 2012; 422(1):146-51. PMC: 3361642. DOI: 10.1016/j.bbrc.2012.04.126. View

Slyper M, Shahar A, Bar-Ziv A, Granit R, Hamburger T, Maly B . Control of breast cancer growth and initiation by the stem cell-associated transcription factor TCF3. Cancer Res. 2012; 72(21):5613-24. DOI: 10.1158/0008-5472.CAN-12-0119. View

Barbisan G, Perez L, Contreras A, Golijow C . TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk. Tumour Biol. 2012; 33(5):1549-56. DOI: 10.1007/s13277-012-0408-1. View

Li H, Sheng Y, Zhang Y, Gao N, Deng X, Sheng X . MicroRNA-138 is a potential biomarker and tumor suppressor in human cervical carcinoma by reversely correlated with TCF3 gene. Gynecol Oncol. 2017; 145(3):569-576. DOI: 10.1016/j.ygyno.2017.01.018. View

Shi W, Liu H, Wu D, Tang Z, Shen Y, Guo L . Stratification analysis and case-control study of relationships between interleukin-6 gene polymorphisms and cervical cancer risk in a Chinese population. Asian Pac J Cancer Prev. 2014; 15(17):7357-62. DOI: 10.7314/apjcp.2014.15.17.7357. View

10.

Caffarel M, Coleman N . Oncostatin M receptor is a novel therapeutic target in cervical squamous cell carcinoma. J Pathol. 2014; 232(4):386-90. PMC: 4260121. DOI: 10.1002/path.4305. View

11.

Tan S, Ismail M, Duski D, Othman N, Ankathil R . FAS c.-671A>G polymorphism and cervical cancer risk: a case-control study and meta-analysis. Cancer Genet. 2017; 211:18-25. DOI: 10.1016/j.cancergen.2017.01.004. View

12.

Bahrami A, Hasanzadeh M, Shahidsales S, Farazestanian M, Hassanian S, Moetamani Ahmadi M . Genetic susceptibility in cervical cancer: From bench to bedside. J Cell Physiol. 2017; 233(3):1929-1939. DOI: 10.1002/jcp.26019. View

13.

Munoz N, Bosch F, de Sanjose S, Herrero R, Castellsague X, Shah K . Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003; 348(6):518-27. DOI: 10.1056/NEJMoa021641. View

14.

Morrison G, Scognamiglio R, Trumpp A, Smith A . Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification. EMBO J. 2015; 35(3):356-68. PMC: 4741304. DOI: 10.15252/embj.201592116. View

15.

Bahrami A, Hasanzadeh M, Shahidsales S, Yousefi Z, Kadkhodayan S, Farazestanian M . Clinical Significance and Prognosis Value of Wnt Signaling Pathway in Cervical Cancer. J Cell Biochem. 2017; 118(10):3028-3033. DOI: 10.1002/jcb.25992. View

16.

Meng J, Wang S, Zhang M, Fan S, Zhang L, Liang C . polymorphism and cancer susceptibility: evidence from 36 case-control studies. Biosci Rep. 2018; 38(6). PMC: 6294616. DOI: 10.1042/BSR20181452. View

17.

Liu H, Lyu D, Zhang Y, Sheng L, Tang N . Association Between the IL-6 rs1800795 Polymorphism and the Risk of Cervical Cancer: A Meta-Analysis of 1210 Cases and 1525 Controls. Technol Cancer Res Treat. 2016; 16(5):662-667. PMC: 5665158. DOI: 10.1177/1533034616672806. View

18.

Ma H, Mallampati S, Lu Y, Sun B, Wang E, Leng X . The Sox4/Tcf7l1 axis promotes progression of BCR-ABL-positive acute lymphoblastic leukemia. Haematologica. 2014; 99(10):1591-8. PMC: 4181255. DOI: 10.3324/haematol.2014.104695. View

19.

Sun P, Shen Y, Gong J, Zhou L, Sheng J, Duan F . A New MicroRNA Expression Signature for Cervical Cancer. Int J Gynecol Cancer. 2016; 27(2):339-343. DOI: 10.1097/IGC.0000000000000863. View

20.

Wang Y, Luo T . LINC00673 rs11655237 Polymorphism Is Associated With Increased Risk of Cervical Cancer in a Chinese Population. Cancer Control. 2018; 25(1):1073274818803942. PMC: 6174653. DOI: 10.1177/1073274818803942. View