Epstein-Barr Virus, Human Papillomavirus and Herpes Simplex Virus 2 Co-presence Severely Dysregulates MiRNA Expression

Overview

Journal Afr J Lab Med

Date 2021 Apr 7

PMID 33824853

Citations 4

Authors

Jude O Okoye

Anthony A Ngokere

Charles C Onyenekwe

Olaposi Omotuyi

Deborah I Dada

Affiliations

Soon will be listed here.

Abstract

This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. This study suggests that malignancies associated with viral co-infection could be diagnosed early by monitoring cluster of differentiation 4+ T-cell counts and serum expression of miR-145 and miR-182.

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