Prolonged Deterioration of Ischemic Brain Energy Metabolism and Acidosis Associated with Hyperglycemia: Human Cerebral Infarction Studied by Serial 31P NMR Spectroscopy

Overview

Journal Ann Neurol

Specialty Neurology

Date 1988 Apr 1

PMID 3382181

Citations 13

Authors

S R Levine

K M Welch

J A Helpern

M Chopp

R Bruce

J Selwa

M B Smith

Affiliations

Soon will be listed here.

Abstract

We report on a patient with a large ischemic hemispherical stroke studied serially by 31P nuclear magnetic resonance spectroscopy. Persistent hyperglycemia was associated with prolonged acidosis in ischemic brain and failure of high-energy phosphate metabolism to recover. These in vivo human data support the concept that hyperglycemia adversely affects ischemic brain metabolism, pH, and clinical outcome.

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