Unsaturated Fatty Acids As a Co-therapeutic Agents in Cancer Treatment

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2021 Apr 6

PMID 33821440

Citations 9

Authors

Zahra Asefy

Asghar Tanomand

Sirus Hoseinnejhad

Zaker Ceferov

Ebrahim Abbasi Oshaghi

Mohsen Rashidi

Affiliations

Soon will be listed here.

Abstract

Chemotherapy is standard treatments for many malignancies. However, in most cases, this method is not able to induce apoptosis and in many cases, with cancer recurrence, leads to patient death. There are several procedure to control and suppress malignant cells, but among these methods, administration of ɷ-3 fatty acids and ɷ-6 fatty due to their destructive effects on cancer cells is more prominent. Many clinical studies have shown beneficial effects of ɷ-3 and ɷ-6 fatty acids in cardiovascular disorders, asthma, rheumatoid arthritis, osteoporosis and in most cancers such as colon, breast, prostate and other malignancies. Studies showed that polyunsaturated fatty acids (PUFAs) have a toxic effect on cancer cells. However, the exact mechanism of how ɷ- fatty acids affect cancer cells is still unknown. In this review alternative issues of malignancies co-treatments agents such as PUFAs have been studied. Also, the latest known PUFAs mechanisms on malignancies have been described.

Citing Articles

Prospecting Pharmacologically Active Biocompounds from the Amazon Rainforest: In Vitro Approaches, Mechanisms of Action Based on Chemical Structure, and Perspectives on Human Therapeutic Use.

de Almada-Vilhena A, Dos Santos O, Machado M, Nagamachi C, Pieczarka J Pharmaceuticals (Basel). 2024; 17(11).

PMID: 39598361 PMC: 11597570. DOI: 10.3390/ph17111449.

Fatty acid composition and anti-cancer activity of essential oil from larvae in combination with zoledronic acid on prostate cancer.

Askari N, Mansouri S Heliyon. 2024; 10(21):e40012.

PMID: 39583822 PMC: 11582447. DOI: 10.1016/j.heliyon.2024.e40012.

Inhibition of the NF-κB/HIF-1α signaling pathway in colorectal cancer by tyrosol: a gut microbiota-derived metabolite.

Guo J, Meng F, Hu R, Chen L, Chang J, Zhao K J Immunother Cancer. 2024; 12(9).

PMID: 39343509 PMC: 11440206. DOI: 10.1136/jitc-2024-008831.

Modulatory effects of miRNAs in doxorubicin resistance: A mechanistic view.

Meinag F, Fatahi M, Vahedian V, Maroufi N, Mosayyebi B, Ahmadi E Funct Integr Genomics. 2024; 24(5):150.

PMID: 39222264 DOI: 10.1007/s10142-024-01431-x.

Obesity and lipid metabolism in the development of osteoporosis (Review).

Wang X, Zhang C, Zhao G, Yang K, Tao L Int J Mol Med. 2024; 54(1).

PMID: 38818830 PMC: 11188977. DOI: 10.3892/ijmm.2024.5385.

References

Chajes V, Bougnoux P . Omega-6/omega-3 polyunsaturated fatty acid ratio and cancer. World Rev Nutr Diet. 2003; 92:133-51. View

Conklin K . Dietary polyunsaturated fatty acids: impact on cancer chemotherapy and radiation. Altern Med Rev. 2002; 7(1):4-21. View

Hammamieh R, Chakraborty N, Miller S, Waddy E, Barmada M, Das R . Differential effects of omega-3 and omega-6 Fatty acids on gene expression in breast cancer cells. Breast Cancer Res Treat. 2006; 101(1):7-16. DOI: 10.1007/s10549-006-9269-x. View

Reddy B, Sugie S . Effect of different levels of omega-3 and omega-6 fatty acids on azoxymethane-induced colon carcinogenesis in F344 rats. Cancer Res. 1988; 48(23):6642-7. View

Shahidi F, Miraliakbari H . Omega-3 (n-3) fatty acids in health and disease: Part 1--cardiovascular disease and cancer. J Med Food. 2005; 7(4):387-401. DOI: 10.1089/jmf.2004.7.387. View

Bougnoux P . n-3 polyunsaturated fatty acids and cancer. Curr Opin Clin Nutr Metab Care. 1999; 2(2):121-6. DOI: 10.1097/00075197-199903000-00005. View

Calder P . Omega-3 fatty acids and inflammatory processes. Nutrients. 2012; 2(3):355-374. PMC: 3257651. DOI: 10.3390/nu2030355. View

Rao C, Hirose Y, Indranie C, Reddy B . Modulation of experimental colon tumorigenesis by types and amounts of dietary fatty acids. Cancer Res. 2001; 61(5):1927-33. View

Tapiero H, Ba G, Couvreur P, Tew K . Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies. Biomed Pharmacother. 2002; 56(5):215-22. DOI: 10.1016/s0753-3322(02)00193-2. View

10.

Mohammadi A, Abbasi Oshaghi E . Effect of garlic on lipid profile and expression of LXR alpha in intestine and liver of hypercholesterolemic mice. J Diabetes Metab Disord. 2014; 13(1):20. PMC: 3937144. DOI: 10.1186/2251-6581-13-20. View

11.

Jiang W, Bryce R, Horrobin D . Essential fatty acids: molecular and cellular basis of their anti-cancer action and clinical implications. Crit Rev Oncol Hematol. 1998; 27(3):179-209. DOI: 10.1016/s1040-8428(98)00003-1. View

12.

Simopoulos A . The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother. 2002; 56(8):365-79. DOI: 10.1016/s0753-3322(02)00253-6. View

13.

Calviello G, Palozza P, Maggiano N, Piccioni E, Franceschelli P, Frattucci A . Cell proliferation, differentiation, and apoptosis are modified by n-3 polyunsaturated fatty acids in normal colonic mucosa. Lipids. 1999; 34(6):599-604. DOI: 10.1007/s11745-999-0404-6. View

14.

Simons K, Vaz W . Model systems, lipid rafts, and cell membranes. Annu Rev Biophys Biomol Struct. 2004; 33:269-95. DOI: 10.1146/annurev.biophys.32.110601.141803. View

15.

Jump D . The biochemistry of n-3 polyunsaturated fatty acids. J Biol Chem. 2001; 277(11):8755-8. DOI: 10.1074/jbc.R100062200. View

16.

Smith W . Nutritionally essential fatty acids and biologically indispensable cyclooxygenases. Trends Biochem Sci. 2007; 33(1):27-37. DOI: 10.1016/j.tibs.2007.09.013. View

17.

Innis S . Essential fatty acids in growth and development. Prog Lipid Res. 1991; 30(1):39-103. DOI: 10.1016/0163-7827(91)90006-q. View

18.

Haag M . Essential fatty acids and the brain. Can J Psychiatry. 2003; 48(3):195-203. DOI: 10.1177/070674370304800308. View

19.

Das U . Essential Fatty acids - a review. Curr Pharm Biotechnol. 2006; 7(6):467-82. DOI: 10.2174/138920106779116856. View

20.

Simopoulos A . Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr. 2002; 21(6):495-505. DOI: 10.1080/07315724.2002.10719248. View