Roles of Phosphatidyl Inositol 3 Kinase Gamma (PI3Kγ) in Respiratory Diseases

Overview

Journal Cell Stress

Date 2021 Apr 6

PMID 33821232

Citations 8

Authors

Valentina Sala

Angela Della Sala

Alessandra Ghigo

Emilio Hirsch

Affiliations

Soon will be listed here.

Abstract

Phosphatidyl inositol 3 kinase gamma (PI3Kγ) is expressed in all the cell types that are involved in airway inflammation and disease, including not only leukocytes, but also structural cells, where it is expressed at very low levels under physiological conditions, while is significantly upregulated after stress. In the airways, PI3Kγ behaves as a trigger or a controller, depending on the pathological context. In this review, the contribution of PI3Kγ in a plethora of respiratory diseases, spanning from acute lung injury, pulmonary fibrosis, asthma, cystic fibrosis and response to both bacterial and viral pathogens, will be commented.

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