Massive Nonatherosclerotic Myocardial Infarction in Sickle Cell Anemia

Overview

Journal Am J Forensic Med Pathol

Specialty Forensic Sciences

Date 1988 Jun 1

PMID 3381795

Citations 6

Authors

W F MCCORMICK

Affiliations

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Abstract

A 30-year-old black man with proven sickle cell anemia died after five years of progressive heart failure and three clinically distinct episodes of myocardial infarction. Autopsy revealed massive ventricular myocardial fibrosis, a large left ventricular aneurysm, and an organized nonatherosclerotic thrombosis of the left coronary artery. Myocardial infarction, unassociated with atherosclerosis, has very rarely been reported in sickle cell anemia. A toxic/lethal level of amitriptyline was found at autopsy.

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