Circulating MiRNAs As Early Indicators of Diet and Physical Activity Response in Women with Metastatic Breast Cancer

Overview

Journal Future Sci OA

Specialty Biotechnology

Date 2021 Apr 5

PMID 33815828

Citations 6

Authors

Jessica Olson

Patricia Sheean

Lauren Matthews

Christopher R Chitambar

Anjishnu Banerjee

Alexis Visotcky

Marcelo Bonini

Melinda Stolley

Affiliations

Soon will be listed here.

Abstract

Treatments for metastatic breast cancer (MBC) improve survival but often impose prolonged symptom burden. We performed molecular characterization of 84 miRNAs in the circulating serum of women with MBC to explore possible early indicators of intervention response. Expression levels of miR-10a-5p and miR-211-5p were downregulated in nonresponders, but upregulated in responders (miR-10a-5p: 0.40-fold and eightfold; miR 211-5p: 0.47-fold and fourfold). miR-205-5p expression was upregulated in both nonresponders and responders, but to a greater extent in responders (1.8-fold and sixfold). Additionally, levels of miR-10a-5p were negatively correlated with expression levels of IL-6 (r = -0.412). Exploration of these pathways may reveal mechanisms of action in lifestyle interventions aimed at improving quality of life and impacting disease progression for women with MBC.

Citing Articles

Advances in Diet and Physical Activity in Breast Cancer Prevention and Treatment.

Khalifa A, Guijarro A, Nencioni A Nutrients. 2024; 16(14).

PMID: 39064705 PMC: 11279876. DOI: 10.3390/nu16142262.

The Effect of Physical Activity/Exercise on miRNA Expression and Function in Non-Communicable Diseases-A Systematic Review.

Afzal M, Greco F, Quinzi F, Scionti F, Maurotti S, Montalcini T Int J Mol Sci. 2024; 25(13).

PMID: 38999923 PMC: 11240922. DOI: 10.3390/ijms25136813.

Epigenetic Biomarkers of Metabolic Responses to Lifestyle Interventions.

Ramos-Lopez O Nutrients. 2023; 15(19).

PMID: 37836535 PMC: 10574040. DOI: 10.3390/nu15194251.

Analysis of circulating extracellular vesicle derived microRNAs in breast cancer patients with obesity: a potential role for Let-7a.

Barone I, Gelsomino L, Accattatis F, Giordano F, Gyorffy B, Panza S J Transl Med. 2023; 21(1):232.

PMID: 37004031 PMC: 10064709. DOI: 10.1186/s12967-023-04075-w.

Exercise training attenuates angiotensin II-induced cardiac fibrosis by reducing POU2F1 expression.

Feng N, Yu H, Wang Y, Zhang Y, Xiao H, Gao W J Sport Health Sci. 2022; 12(4):464-476.

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