Relationship Between Sleep-Disordered Breathing and Neurogenic Obesity in Adults With Spinal Cord Injury

Overview

Journal Top Spinal Cord Inj Rehabil

Specialties Emergency Medicine
Rehabilitation Medicine

Date 2021 Apr 5

PMID 33814886

Citations 5

Authors

Michael A Kryger

Veronica J Chehata

Affiliations

Soon will be listed here.

Abstract

Spinal cord injury (SCI) substantially increases the risk of neurogenic obesity, diabetes, and metabolic syndrome. Much like in the general population, a discussion of these syndromes in SCI would be incomplete without acknowledging the association of SCI with sleep-disordered breathing (SDB). This article will outline the interplay between obesity and obstructive sleep apnea (OSA), discussing the pathophysiology of obesity in OSA both for the general population and SCI population. The role of insulin resistance in SDB and SCI will also be examined. The epidemiology and pathophysiology of OSA and central sleep apnea in SCI are discussed through an examination of current evidence, followed by a review of central sleep apnea in SCI. Principles of diagnosis and management of SDB will also be discussed. Because sleep deprivation in itself can be a risk factor for developing obesity, the significance of comorbid insomnia in SCI is explored. Ultimately, a thorough sleep history, testing, and treatment are key to improving the sleep of individuals with SCI and to potentially reducing the impact of neurogenic obesity and metabolic syndrome.

Citing Articles

Prevalences of sleep-related breathing disorders and severity factors in chronic spinal cord injury and abled-bodied individuals undergoing rehabilitation: a comparative study.

Souza Bastos P, Amaral T, Yehia H, Tavares A J Clin Sleep Med. 2024; 20(7):1119-1129.

PMID: 38420961 PMC: 11217642. DOI: 10.5664/jcsm.11084.

Serendipity.

Kryger M Sleep Adv. 2023; 4(1):zpad029.

PMID: 37744181 PMC: 10516468. DOI: 10.1093/sleepadvances/zpad029.

Physical and emotional consequences of excess weight as experienced by individuals with spinal cord injuries.

LaVela S, Wu J, Harris A, Frayne S, Nevedal A, Arnow K J Spinal Cord Med. 2022; 47(3):412-422.

PMID: 36448929 PMC: 11044741. DOI: 10.1080/10790268.2022.2097994.

Pathophysiology, Classification and Comorbidities after Traumatic Spinal Cord Injury.

Guest J, Datta N, Jimsheleishvili G, Gater Jr D J Pers Med. 2022; 12(7).

PMID: 35887623 PMC: 9323191. DOI: 10.3390/jpm12071126.

Concomitant Brain Injury and Spinal Cord Injury Management Strategies: A Narrative Review.

Valbuena Valecillos A, Gater Jr D, Alvarez G J Pers Med. 2022; 12(7).

PMID: 35887605 PMC: 9324293. DOI: 10.3390/jpm12071108.

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