The Oral Administration of Extract Improves Physical Performance Through LDHA Modulation

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2021 Apr 3

PMID 33809377

Citations 5

Authors

Jung Ho Han

MinJeong Kim

Hee-Jin Choi

Jung Sook Jin

Syng-ook Lee

Sung-Jin Bae

Dongryeol Ryu

Ki-Tae Ha

Affiliations

Soon will be listed here.

Abstract

Muscle fatigue is induced by an acute or chronic physical performance inability after excessive physical activity often associated with lactate accumulation, the end-product of glycolysis. In this study, the water-extracted roots of L., a herbal medicine traditionally used for inflammation and diarrhea, reduced the activities of lactate dehydrogenase A (LDHA) in in vitro enzyme assay myoblast C2C12 cells and murine muscle tissue. Physical performance measured by a treadmill test was improved in the -administrated group. The analysis of mouse serum and tissues showed significant changes in lactate levels. Among the proteins related to energy metabolism-related physical performance, phosphorylated-AMP-activated protein kinase alpha (AMPKα) and peroxisome proliferator-activated receptor-coactivator-1 alpha (PGC-1α) levels were enhanced, whereas the amount of LDHA was suppressed. Therefore, might be a candidate for improving physical performance via inhibiting LDHA and glycolysis.

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