Reproductive Chances of Men with Azoospermia Due to Spermatogenic Dysfunction

Overview

Journal J Clin Med

Specialty General Medicine

Date 2021 Apr 3

PMID 33807489

Citations 14

Authors

Caroline Kang

Nahid Punjani

Peter N Schlegel

Affiliations

Soon will be listed here.

Abstract

Non-obstructive azoospermia (NOA), or lack of sperm in the ejaculate due to spermatogenic dysfunction, is the most severe form of infertility. Men with this form of infertility should be evaluated prior to treatment, as there are various underlying etiologies for NOA. While a significant proportion of NOA men have idiopathic spermatogenic dysfunction, known etiologies including genetic disorders, hormonal anomalies, structural abnormalities, chemotherapy or radiation treatment, infection and inflammation may substantively affect the prognosis for successful treatment. Despite the underlying etiology for NOA, most of these infertile men are candidates for surgical sperm retrieval and subsequent use in intracytoplasmic sperm injection (ICSI). In this review, we describe common etiologies of NOA and clinical outcomes following surgical sperm retrieval and ICSI.

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