The Relationships Between Serum DHEA-S and AMH Levels in Infertile Women: A Retrospective Cross-Sectional Study

Overview

Journal J Clin Med

Specialty General Medicine

Date 2021 Apr 3

PMID 33803980

Citations 4

Authors

Li-Te Lin

Kuan-Hao Tsui

Affiliations

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Abstract

The relationship between serum dehydroepiandrosterone sulphate (DHEA-S) and anti-Mullerian hormone (AMH) levels has not been fully established. Therefore, we performed a large-scale cross-sectional study to investigate the association between serum DHEA-S and AMH levels. The study included a total of 2155 infertile women aged 20 to 46 years who were divided into four quartile groups (Q1 to Q4) based on serum DHEA-S levels. We found that there was a weak positive association between serum DHEA-S and AMH levels in infertile women (r = 0.190, < 0.001). After adjusting for potential confounders, serum DHEA-S levels positively correlated with serum AMH levels in infertile women (β = 0.103, < 0.001). Infertile women in the highest DHEA-S quartile category (Q4) showed significantly higher serum AMH levels ( < 0.001) compared with women in the lowest DHEA-S quartile category (Q1). The serum AMH levels significantly increased across increasing DHEA-S quartile categories in infertile women ( = 0.014) using generalized linear models after adjustment for potential confounders. Our data show that serum DHEA-S levels are positively associated with serum AMH levels.

Citing Articles

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References

Sahu P, Gidwani B, Dhongade H . Pharmacological activities of dehydroepiandrosterone: A review. Steroids. 2019; 153:108507. DOI: 10.1016/j.steroids.2019.108507. View

Wang T, Chang C, Wu H, Chiu Y, Chen C, Wang H . Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo development. Fertil Steril. 2006; 86(5):1392-401. DOI: 10.1016/j.fertnstert.2006.03.064. View

Hu Q, Hong L, Nie M, Wang Q, Fang Y, Dai Y . The effect of dehydroepiandrosterone supplementation on ovarian response is associated with androgen receptor in diminished ovarian reserve women. J Ovarian Res. 2017; 10(1):32. PMC: 5418866. DOI: 10.1186/s13048-017-0326-3. View

Tsai H, Hsieh Y, Hsieh J, Chang C, Yang C, Yang J . Mitochondria DNA deletion and copy numbers of cumulus cells associated with in vitro fertilization outcomes. J Reprod Med. 2011; 55(11-12):491-7. View

Zhang Y, Zhang C, Shu J, Guo J, Chang H, Leung P . Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis. Hum Reprod Update. 2020; 26(2):247-263. DOI: 10.1093/humupd/dmz046. View

Monte A, Barros V, Santos J, Menezes V, Cavalcante A, Gouveia B . Immunohistochemical localization of insulin-like growth factor-1 (IGF-1) in the sheep ovary and the synergistic effect of IGF-1 and FSH on follicular development in vitro and LH receptor immunostaining. Theriogenology. 2019; 129:61-69. DOI: 10.1016/j.theriogenology.2019.02.005. View

Yilmaz N, Uygur D, Inal H, Gorkem U, Cicek N, Mollamahmutoglu L . Dehydroepiandrosterone supplementation improves predictive markers for diminished ovarian reserve: serum AMH, inhibin B and antral follicle count. Eur J Obstet Gynecol Reprod Biol. 2013; 169(2):257-60. DOI: 10.1016/j.ejogrb.2013.04.003. View

Kelsey T, Wright P, Nelson S, Anderson R, Wallace W . A validated model of serum anti-müllerian hormone from conception to menopause. PLoS One. 2011; 6(7):e22024. PMC: 3137624. DOI: 10.1371/journal.pone.0022024. View

Baumgarten S, Convissar S, Fierro M, Winston N, Scoccia B, Stocco C . IGF1R signaling is necessary for FSH-induced activation of AKT and differentiation of human Cumulus granulosa cells. J Clin Endocrinol Metab. 2014; 99(8):2995-3004. PMC: 4121023. DOI: 10.1210/jc.2014-1139. View

10.

Taieb J, Grynberg M, Pierre A, Arouche N, Massart P, Belville C . FSH and its second messenger cAMP stimulate the transcription of human anti-Müllerian hormone in cultured granulosa cells. Mol Endocrinol. 2011; 25(4):645-55. PMC: 5417263. DOI: 10.1210/me.2010-0297. View

11.

Broer S, van Disseldorp J, Broeze K, Dolleman M, Opmeer B, Bossuyt P . Added value of ovarian reserve testing on patient characteristics in the prediction of ovarian response and ongoing pregnancy: an individual patient data approach. Hum Reprod Update. 2012; 19(1):26-36. DOI: 10.1093/humupd/dms041. View

12.

Zhao J, Taverne M, van der Weijden G, M M Bevers , Van Den Hurk R . Insulin-like growth factor-I (IGF-I) stimulates the development of cultured rat pre-antral follicles. Mol Reprod Dev. 2001; 58(3):287-96. DOI: 10.1002/1098-2795(200103)58:3<287::AID-MRD7>3.0.CO;2-G. View

13.

Moolhuijsen L, Visser J . Anti-Müllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function. J Clin Endocrinol Metab. 2020; 105(11). PMC: 7486884. DOI: 10.1210/clinem/dgaa513. View

14.

Almeida Santos T, El Shourbagy S, St John J . Mitochondrial content reflects oocyte variability and fertilization outcome. Fertil Steril. 2006; 85(3):584-91. DOI: 10.1016/j.fertnstert.2005.09.017. View

15.

Hickey T, Marrocco D, Amato F, Ritter L, Norman R, Gilchrist R . Androgens augment the mitogenic effects of oocyte-secreted factors and growth differentiation factor 9 on porcine granulosa cells. Biol Reprod. 2005; 73(4):825-32. DOI: 10.1095/biolreprod.104.039362. View

16.

Xie M, Zhong Y, Xue Q, Wu M, Deng X, Santos H . Impact of dehydroepianrosterone (DHEA) supplementation on serum levels of insulin-like growth factor 1 (IGF-1): A dose-response meta-analysis of randomized controlled trials. Exp Gerontol. 2020; 136:110949. DOI: 10.1016/j.exger.2020.110949. View

17.

Astapova O, Minor B, Hammes S . Physiological and Pathological Androgen Actions in the Ovary. Endocrinology. 2019; 160(5):1166-1174. PMC: 6937455. DOI: 10.1210/en.2019-00101. View

18.

Labrie F, Luu-The V, Labrie C, Simard J . DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology. Front Neuroendocrinol. 2001; 22(3):185-212. DOI: 10.1006/frne.2001.0216. View

19.

Yeung T, Chai J, Li R, Lee V, Ho P, Ng E . A randomized, controlled, pilot trial on the effect of dehydroepiandrosterone on ovarian response markers, ovarian response, and in vitro fertilization outcomes in poor responders. Fertil Steril. 2014; 102(1):108-115.e1. DOI: 10.1016/j.fertnstert.2014.03.044. View

20.

Pigny P, Merlen E, Robert Y, Cortet-Rudelli C, Decanter C, Jonard S . Elevated serum level of anti-mullerian hormone in patients with polycystic ovary syndrome: relationship to the ovarian follicle excess and to the follicular arrest. J Clin Endocrinol Metab. 2003; 88(12):5957-62. DOI: 10.1210/jc.2003-030727. View