Roles of Microglial Ion Channel in Neurodegenerative Diseases

Overview

Journal J Clin Med

Specialty General Medicine

Date 2021 Apr 3

PMID 33802786

Citations 9

Authors

Alexandru Cojocaru

Emilia Burada

Adrian-Tudor Balseanu

Alexandru-Florian Deftu

Bogdan Catalin

Aurel Popa-Wagner

Eugen Osiac

Affiliations

Soon will be listed here.

Abstract

As the average age and life expectancy increases, the incidence of both acute and chronic central nervous system (CNS) pathologies will increase. Understanding mechanisms underlying neuroinflammation as the common feature of any neurodegenerative pathology, we can exploit the pharmacology of cell specific ion channels to improve the outcome of many CNS diseases. As the main cellular player of neuroinflammation, microglia play a central role in this process. Although microglia are considered non-excitable cells, they express a variety of ion channels under both physiological and pathological conditions that seem to be involved in a plethora of cellular processes. Here, we discuss the impact of modulating microglia voltage-gated, potential transient receptor, chloride and proton channels on microglial proliferation, migration, and phagocytosis in neurodegenerative diseases.

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